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Heat shock proteins with an emphasis on HSP 60

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Abstract

Heat shock phenomenon is a process by which cells express a set of proteins called heat shock proteins (HSPs) against heat stress. HSPs include several families depending upon the molecular weight of the respective protein. Among the different HSPs, The HSP60 is one of the main components representing the framework of chaperone system. HSP60 plays a myriad number of roles like chaperoning, thermotolerance, apoptosis, cancer, immunology and embryonic development. In this review we discussed briefly the general knowledge and focussed on HSP60 in terms of structure, regulation and function in various physiological and pathological conditions.

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Acknowledgements

The authors acknowledge the Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh—India and Central University of Kashmir, Jammu and Kashmir—India. The author Rafiq Lone also acknowledged the Grant (PDF/2017/003066) in the form of NPDF, SERB, DST-GOI.

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  1. Pharmacology and Toxicology Laboratory, Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

    Javid Ahmad Malik

  2. Department of Botany, Central University of Kashmir, Jammu and Kashmir, India

    Rafiq Lone

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  1. Javid Ahmad Malik
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  2. Rafiq Lone
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JAM and RL have contributed equally in preparation of manuscript and have read manuscript before publication.

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Correspondence to Rafiq Lone.

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Malik, J.A., Lone, R. Heat shock proteins with an emphasis on HSP 60. Mol Biol Rep 48, 6959–6969 (2021). https://doi.org/10.1007/s11033-021-06676-4

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