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Multicomponent Reactions Based on In Situ Generated Isocyanides for the Construction of Heterocycles

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Chemistry of Heterocyclic Compounds Aims and scope

Isocyanides have a long history, high versatility and have been used widely in various research fields, especially in multicomponent synthesis. Despite their many applications, isocyanides are strongly fetid, labile, and suspect of toxicity, thus researchers worldwide are hesitant to use them. The in situ generation and capturing synthetic protocols avoid environmental exposure and thus would be the sustainable alternative for the conventional use of isocyanides. This issue is consequently the main focus of the present review. The literature reports published in 2005–2020 are analyzed and categorized based on the class of heterocycles. The reaction conditions along with proposed mechanisms providing conventional approaches and novel elements are discussed aiming to deliver the readers an easy understanding of in situ versions of isocyanide-based multicomponent reactions and to provide insights for further investigations.

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Authors and Affiliations

  1. Department of Chemistry, N. M. A. M. Institute of Technology, Visvesvaraya Technological University, Nitte 574110, Udupi District, Belagavi, Karnataka, India

    Subrahmanya Ishwar Bhat

  2. Centre for Nano and Material Sciences, JAIN Deemed-to-be-University, Jain Global Campus, Bengaluru, Karnataka, 562112, India

    Madhuprasad Kigga

  3. Department of Chemistry, School of Physics and Chemistry, Alzahra University, Vanak, P.O. Box 1993891176, Tehran, Iran

    Majid M. Heravi

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  1. Subrahmanya Ishwar Bhat
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  2. Madhuprasad Kigga
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  3. Majid M. Heravi
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Correspondence to Subrahmanya Ishwar Bhat or Majid M. Heravi.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(7/8), 709–719

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Bhat, S.I., Kigga, M. & Heravi, M.M. Multicomponent Reactions Based on In Situ Generated Isocyanides for the Construction of Heterocycles. Chem Heterocycl Comp 57, 709–719 (2021). https://doi.org/10.1007/s10593-021-02972-w

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