Elsevier

Respiratory Medicine

Volume 188, November 2021, 106600
Respiratory Medicine

Short communication
Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients

https://doi.org/10.1016/j.rmed.2021.106600Get rights and content
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Highlight

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    LCQ and VAS are two tools to assess cough related quality of life.

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    LCQ and VAS in sarcoidosis are influenced by FeV1 and BMI

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    Serological parameters are not associated with LCQ score

Abstract

Sarcoidosis is a granulomatous disease that mainly manifests within the lungs and may thereby impair lung function. Beyond and independently from organ impairment, sarcoidosis may affect quality of life which can be quantified by questionnaires. The Leicester Cough Questionnaire (LCQ) has been developed to assess cough-related quality of life. We analysed data from a prospectively collected cohort of sarcoidosis patients for validation of the German LCQ version. Our analyses demonstrated that LCQ values add additional information beyond routinely monitored parameters (e.g. lung function). Only FeV1 and BMI slightly influence LCQ scores, where all other parameters tested did not correlate with LCQ scores. In summary, LCQ is a valuable tool providing information on the patient’ quality of life beyond routine follow-up parameters. FeV1 and BMI may represent treatable traits to reduce cough-related disease burden.

Keywords

Sarcoidosis
Quality of life
Cough
Leicester cough questionnaire
FeV1
Body mass index
BMI
Adiposity

Abbreviations

ACE
angiotensin-converting enzyme
BMI
body mass index
DLCO
Diffusion Capacity of the Lungs for Carbon Monoxide
FeV1
forced expiratory volume in 1 s
FVC
forced vital capacity
LCQ
Leicester Cough Questionnaire
QoL
quality of life
sIL2R
soluble interleukin-2 receptor
TLC
total lung capacity
VAS
Visual analogue scale (for cough)

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