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Two Cu(II)-Based Coordination Polymers: Magnetic Properties and Treatment Activity on the Restless Leg Syndrome

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Abstract

By applying the mixed-ligand approach, two coordination polymers (CPs) based on Cu(II) of {[Cu(3-bpdb)(fum)(H2O)2]}n (1, 3-bpdb = 1,4-bis(3-pyridyl)-2,3-diaza-1,3-butadiene and fum = fumarate) and {[Cu4(4-bpdb)2(suc)3(OH)2]·5(H2O)}n (2, 4-bpdb = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene and suc = succinate) were triumphantly synthesized via a slow volatilization method. The magnetic properties for complexes 1 and 2 have been studied, which reveal their antiferromagnet interactions among the metal ions. Their protective activity on the restless leg syndrome was evaluated. First of all, the tyrosine hydroxylase relative expression in dopaminergic neuron of anterior horn of spinal cord was detected through the real time reverse transcription-polymerase chain reaction (RT-PCR) method. In addition to this, the inflammatory response in the anterior horn of spinal cord was also assessed by determining the inflammatory cytokines levels by enzyme linked immunosorbent assay (ELISA) kit.

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Data Availability

The six-coordinated Cu(II) ion of 1 (Fig. S1), the 1D Cu-fum chain of 1 (Fig. S2), the coordination environments for the Cu(II) ions in 2 (Fig. S3), the PXRD patterns for complexes 1 and 2 (Fig. S4), The TGA curves for complexes 1 and 2 (Fig. S5), Bond lengths for 1 (Table S1), bond angles for 1 (Table S2), Bond lengths for 2 (Table S3), Bond angles for 2 (Table S4), the information could be found in the supporting information file.

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Acknowledgements

This work was supported by grants from Key R & D-Basic Research Projects (2018-ZDYF-JCYJ-62).

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Authors and Affiliations

  1. Department of Neurology, Tangdu Hospital, Air Force Military Medical University, Xi’an, Shannxi, China

    Yan Liu & Hui-Li Zou

  2. Sleep Medicine Center, Peking University Internationnal Hospital, Beijing, China

    Wei Zhang

  3. Department of Neurology, Central Hospital of Wei’nan, Wei’nan, Shannxi, China

    Jiang-Bo Nan & Kai-Xiong Lei

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  1. Yan Liu
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Liu, Y., Zhang, W., Nan, JB. et al. Two Cu(II)-Based Coordination Polymers: Magnetic Properties and Treatment Activity on the Restless Leg Syndrome. J Inorg Organomet Polym 32, 134–142 (2022). https://doi.org/10.1007/s10904-021-02092-0

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