Journal of Biological Chemistry
Volume 297, Issue 4, October 2021, 101159
Research ArticleSpreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β
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open access
Keywords
Alzheimer's disease
tau protein
amyloid-beta
transgenic mice
stereotactic injection
Abbreviations
Aβ
amyloid-β
Aβo
Aβ oligomer
AD
Alzheimer's disease
APP
amyloid precursor protein
AZD
AZD0530
DAB
3,3'-diaminobenzidine
ddH2O
double-distilled water
DIV
days in vitro
DKI
double knock-in mice
EC
entorhinal cortex
GFAP
glial fibrillary acidic protein
hTau
humanized tau
IHC
immunohistochemistry
KI
knock-in
MAPT
microtubule-associated protein tau
NFT
neurofibrillary tangle
NP
neuritic plaque
NT
neuropil thread
PGRN
progranulin
ROI
region of interest
RSA
retrosplenial area
RT
room temperature
TBST
Tris-buffered saline + 0.1% Tween-20 detergent
ThioS
thioflavin S
WB
Western blotting
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© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.