ORIGINAL ARTICLEHigh-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS
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Graphical abstract
A high-throughput screening (HTS) method based on the combinational use of biolayer interferometry (BLI) and UHPLC‒DAD-Q/TOF-MS/MS is developed. PPAC, DTA, and TA are identified from Kai-Xin-San as potent Aβ inhibitors.
KEY WORDS
Alzheimer's disease
High-throughput screening
Biolayer interferometry
UHPLC−DAD-Q/TOF-MS/MS
Kai-Xin-San
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Peer review under responsibility of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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These authors made equal contributions to this work.
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