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Omentin-1 and its relationship with inflammatory factors in maternal plasma and visceral adipose tissue of women with gestational diabetes mellitus

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Abstract

Purpose

To investigate the association of omentin-1 and inflammatory factors in serum and visceral adipose tissue (VAT) of women with gestational diabetes mellitus (GDM) compared to normal pregnant (NP) subjects. Furthermore, to examine their correlation with maternal clinical characteristics.

Methods

We compared 116 GDM women to 115 NP women, at the time of cesarean section. Circulating omentin-1 and pro-inflammatory (IL-1β, IL-6, TNF-α), and anti-inflammatory cytokines (IL-1RA, IL-10) were examined. Moreover, their mRNA expression in VAT, along with inflammatory factors involved in the NF-κB pathway (TLR2, TLR4, NF-κB, IKκB), were examined.

Results

Circulating omentin-1 (p = 0.022) was lower and circulating IL-1-β, IL-1RA, as well as IL-10 (p = 0.005, p = 0.007, and p = 0.015, respectively), were higher in GDM compared to NP women. Omentin-1 correlated negatively with pre-pregnancy and gestational BMI, and HOMA-IR in all women, but was not associated with cytokines. TLR2, TLR4, IL-1β, IL-1RA, IL-6, IL-10 mRNA expression in VAT was lower in GDM compared with controls (p < 0.05 all). In multivariate analysis, BMI at delivery was significantly correlated to omentin-1 concentrations in all and NP subjects. In addition, omentin-1 expression was correlated to inflammatory gene expression in all, GDM and NP, women (p < 0.05 all).

Conclusion

Serum levels and VAT gene expression of omentin-1 are not independently linked to GDM; notwithstanding, GDM women have a VAT-altered inflammatory status. In addition, no systemic association between omentin-1 and inflammatory factors was found, whereas associations between their expression in all women were observed, indicating that expression of these adipokines is linked between them regardless of GDM.

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Availability of data and material

The data used to support the findings of this study are available from the corresponding author by request.

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Funding

This study was supported by scientific grants from Instituto Mexicano del Seguro Social (FIS/IMSS/PROT/G18/1826). RS, JVO, EMA, and RGD hold a fellowship from the National System of Investigators (Consejo Nacional de Ciencia y Tecnología).

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Authors and Affiliations

  1. Hospital of Gynecology and Obstetrics 221, Instituto Mexicano del Seguro Social, Toluca, State of Mexico, México

    M. I. Peña-Cano

  2. Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Cuauhtémoc 330, Mexico City, 06720, México

    J. Valencia-Ortega & R. Saucedo

  3. Faculty of Chemistry, Universidad Autonoma del Estado de Mexico, Toluca, State of Mexico, México

    E. Morales-Ávila

  4. Hospital of Gynecology and Obstetrics 3, Medical Center La Raza, Instituto Mexicano del Seguro Social, Mexico City, México

    M. F. Díaz-Velázquez

  5. Unit of Research in Clinical Epidemiology, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, México

    R. Gómez-Díaz

Authors
  1. M. I. Peña-Cano
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  2. J. Valencia-Ortega
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  3. E. Morales-Ávila
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  4. M. F. Díaz-Velázquez
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  5. R. Gómez-Díaz
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  6. R. Saucedo
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Contributions

MIPC, JVO, and RS planned and designed the study. MIPC, and JVO performed laboratory biomarker analysis. EMA, MFDV, RGD, and RS drafted the manuscript. MIPC, and RS performed the data analysis. All authors provided significant intellectual contribution in interpreting data and critical review of the manuscript.

Corresponding author

Correspondence to R. Saucedo.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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The study protocol was approved by the Institutional Review Board of the Instituto Mexicano del Seguro Social (IMSS) in Mexico City (R-2018-785-026).

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All participants gave written informed consent.

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Peña-Cano, M.I., Valencia-Ortega, J., Morales-Ávila, E. et al. Omentin-1 and its relationship with inflammatory factors in maternal plasma and visceral adipose tissue of women with gestational diabetes mellitus. J Endocrinol Invest 45, 453–462 (2022). https://doi.org/10.1007/s40618-021-01671-9

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  • DOI: https://doi.org/10.1007/s40618-021-01671-9

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