Abstract
In this study, it was aimed to evaluate the dorsal striatum nuclei of patients diagnosed with Functional Neurological Disorder by texture analysis method from magnetic resonance imaging images and to compare them with healthy controls. Study groups consisted of 20 female patients and 20 healthy women. The brains of patients and controls were scanned for high-resolution images with a 1.5T scanner using the sagittal plane and 3D spiral fast spin echo sequence. Using the texture analysis method, mean, standard deviation, minimum, maximum, median, variance, entropy, size %L, size %U, size %M, kurtosis, skewness and homogeneity values of the dorsal striatum nuclei were calculated from the images. The data were compared with comparison tests according to Kolmogorov–Smirnov test results. There was no statistically significant difference between paired regions in terms of texture analysis findings in the cross-sectional images of the participants. In patients, mean, standard deviation, minimum, maximum, median, variance and entropy values for the putamen nucleus, and mean, standard deviation, minimum, maximum, median, variance, entropy and kurtosis values for the caudate nucleus were found significantly higher than controls. Additional receiver operating characteristic curve and logistic regression analyzes were performed. The implications of the results of the study are that there are significant microstructural changes in the dorsal striatum nuclei of patients and their reflection on brain images. Texture analysis is a useful technique to show tissue changes in the dorsal striatum of patients using images. It is highly recommended to use texture analysis to identify and evaluate potentially affected areas of the brain in new studies.
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This research was financially supported by Firat University Scientific Research Projects Unit (FUBAP Project No: TF.13.40).
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Author contributions included conception and study design (MB and SB), data collection or acquisition (SB), statistical analysis (MB), interpretation of results (MB and SB), drafting the manuscript work or revising it critically for important intellectual content (MB and SB) and approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (MB and SB).
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Baykara, M., Baykara, S. Texture analysis of dorsal striatum in functional neurological (conversion) disorder. Brain Imaging and Behavior 16, 596–607 (2022). https://doi.org/10.1007/s11682-021-00527-3
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DOI: https://doi.org/10.1007/s11682-021-00527-3