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Planta Med 2022; 88(08): 664-677
DOI: 10.1055/a-1580-7782
Biological and Pharmacological Activity
Reviews

Herbal Medicines in the Treatment of Dyspepsia: An Overview

Thaise Boeing
1   Pharmaceutical Sciences Graduate Program, University of Vale do Itajaí, Itajaí, Brazil.
,
Priscila de Souza 
1   Pharmaceutical Sciences Graduate Program, University of Vale do Itajaí, Itajaí, Brazil.
,
Luisa Mota da Silva
1   Pharmaceutical Sciences Graduate Program, University of Vale do Itajaí, Itajaí, Brazil.
,
Arquimedes Gasparotto Junior 
2   Laboratory of Cardiovascular Pharmacology (LaFac), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil
› Author AffiliationsSupported by: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Supported by: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
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Abstract

This review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The data availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.

Key words

antiulcer - gastroprotective - Helicobacter pylori - medicinal plants - natural products - prokinetic

Supporting Information

    Table 1S. Medicinal plants with studies reporting gastroprotective action are available as Supporting Information.

  • Supporting Information


Publication History

Received: 08 February 2021

Accepted after revision: 03 August 2021

Article published online:
02 September 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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