Cell Stem Cell
Volume 28, Issue 9, 2 September 2021, Pages 1503-1504
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Refined transcriptional blueprint of human preimplantation embryos

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Despite being a biologically fundamental question, the precise timing of lineage specification during human preimplantation development remains elusive. In this issue of Cell Stem Cell, Meistermann et al. (2021) refine our view through time-lapse embryo staging and single-cell sequencing and challenge the concept of a human inner cell mass.

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