G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)
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Keywords
G protein-coupled receptors
G protein subnits
Plasma membrane effector
GPCR oligomerization
GPCR allosterism
Abbreviations1
AC
adenylate cyclase
AKAP
A-kinase anchoring protein
AMPAR
ionotropic glutamate AMPA receptors
BiBC or BiFC
bimolecular bioluminescence or fluorescence complementation
BRET or FRET
bioluminescence or fluorescence resonance energy transfer
CT or NT
carboxy terminus or amino terminus
ER
endoplasmic reticulum
FRAP
fluorescence recovery after photobleaching
GEMMA
GPCR-effector macromolecular membrane assembly
GPCR
G protein-coupled receptor
Kir
inwardly rectifying potassium channel
PDZ
PSD-95/Discs large/Zona occludens-1
PKA
protein kinase A
PM-effector
plasma membrane-effector
PIP2
phosphatidylinositol 4,5-bisphosphate
PLC
phospholipase C
RAMP
Receptor activity-modifying protein
Rluc
Renilla luciferase
TM
transmembrane
YFP
yellow fluorescence protein.
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- 1
GPCR nomenclature used in the current review follows the guidelines of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (https://www.guidetopharmacology.org/nomenclature.jsp) and adds an ‘R’ at the end as an abbreviation of ‘receptor’.
Published by Elsevier Inc.