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Pneumococcal Antibody Function for Immunologic Evaluation: Normal Results in Older Adults, and a Novel Analytical Model for Vaccine Response

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Fig. 1

Abbreviations

PnAF:

Pneumococcal antibody function

MOPA:

Multiplex opsonophagocytosis assay

PCV13:

13-Valent pneumococcal conjugate vaccine

IgG:

Immunoglobulin G

ELISA:

Enzyme-linked immunosorbent assay

PIDDs:

Primary immunodeficiency diseases

OI:

Opsonization index

WHO:

World Health Organization

GMT:

Geometric mean titer

C1:

Cutoff 1

C2:

Cutoff 2

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Funding

This work was supported by the National Institutes of Health grants 5T32HL105346-9 (David LaFon) and HHSN272201200005C (Moon Nahm). The funding source had no direct role in study design, execution, or publication.

The University of Alabama at Birmingham (UAB) has intellectual property rights to several opsonophagocytosis assay reagents developed in Dr. Moon Nahm’s laboratory, and all authors are UAB employees. The authors declare no competing interests.

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Authors and Affiliations

  1. Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama At Birmingham, Birmingham, AL, USA

    David LaFon, Robert Burton, Mark Dransfield & Moon Nahm

  2. UAB Lung Health Center, University of Alabama At Birmingham, Birmingham, AL, USA

    David LaFon & Mark Dransfield

  3. Division of Preventive Medicine, University of Alabama At Birmingham, Birmingham, AL, USA

    Young-il Kim

  4. Birmingham VA Medical Center, Birmingham, AL, USA

    Mark Dransfield

  5. Department of Microbiology, University of Alabama At Birmingham, Birmingham, AL, USA

    Moon Nahm

Authors
  1. David LaFon
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  2. Young-il Kim
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  3. Robert Burton
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  4. Mark Dransfield
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  5. Moon Nahm
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Corresponding author

Correspondence to David LaFon.

Additional information

Some of the material included in this manuscript was previously presented in abstract format as a poster presentation at the 2019 IDWeek conference in Washington, D.C.

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LaFon, D., Kim, Yi., Burton, R. et al. Pneumococcal Antibody Function for Immunologic Evaluation: Normal Results in Older Adults, and a Novel Analytical Model for Vaccine Response. J Clin Immunol 41, 1964–1968 (2021). https://doi.org/10.1007/s10875-021-01126-z

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  • DOI: https://doi.org/10.1007/s10875-021-01126-z

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