Shanpanootols G and H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar and Their Vpr Inhibitory Activities

Nwet Nwet Win; Takeshi Kodama; Zin Paing Htoo; Saw Yu Yu Hnin; Hla Ngwe; Ikuro Abe; Hiroyuki Morita

doi:10.1248/cpb.c21-00326

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Shanpanootols G and H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar and Their Vpr Inhibitory Activities

Nwet Nwet Win, Takeshi Kodama, Zin Paing Htoo, Saw Yu Yu Hnin, Hla Ngwe, Ikuro Abe, Hiroyuki Morita

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Keywords: shanpanootol G, shanpanootol H, Δ^8(14),15-isopimarane diterpenoid, Kaempferia pulchra, Viral protein R (Vpr) inhibitory activity, TREx-HeLa-Vpr cell

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Supplementary material

2021 Volume 69 Issue 9 Pages 913-917

DOI https://doi.org/10.1248/cpb.c21-00326

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Abstract

Two new trihydroxy derivative of Δ^8(14),15-isopimarane diterpenoids, shanpanootols G (1) and H (2), along with three known analogues were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Shan State of Myanmar. The structures of these compounds including their absolute configurations were elucidated by the combination of one dimensional (1D) and 2D-NMR spectroscopic methods, high resolution mass spectrometric technique, and the experimental and the calculated electronic circular dichroism (ECD) data. The isopimarane diterpenoids (1–5) were tested for their Viral protein R (Vpr) inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootol H (2) and (1R,2S,5S,9R,10S,13R)-1,2-dihydroxypimara-8(14),15-dien-7-one (4) exhibited anti-Vpr activities at the 5 µM treated dose.

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