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Selenium Deficiency Promotes Oxidative Stress-Induced Mastitis via Activating the NF-κB and MAPK Pathways in Dairy Cow

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Abstract

Selenium (Se) is an antioxidant and immunomodulator that can participate in the control of specific endocrine pathways. Disturbance of redox homeostasis is closely related to the pathogenesis of many diseases. Se is also an important nutrient element for dairy cows. First, oxidative stress (OS) induced by Se deficiency was investigated along with a possible mechanism of its induction of mammary gland inflammation. This investigation used in vivo and in vitro experiments for verification. Once the OS response was triggered, the activity of antioxidant enzymes was reduced by regulation of the concentration of Se, which led to the accumulation of ROS. TNF-α, IL-1β, and IL-6 secretion was promoted to activate the NF-κB/MAPK signaling pathway. This process further promoted the accumulation of cytokines that aggravated the inflammatory response. Herein, it was verified that Se deficiency induces OS, which leads to ROS accumulation and the secretion of inflammatory factors to activate the NF-κB/MAPK signaling pathway and promote the occurrence of mastitis.

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Data Availability

The data of this study will be made available on reasonable request.

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Funding

This work was supported by the National Natural Science Foundation of China (NO. 31802262).

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Authors and Affiliations

  1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Yanhe Zhang, Yueqi Xu, Bowen Chen, Bing Zhao & Xue-jiao Gao

Authors
  1. Yanhe Zhang
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  2. Yueqi Xu
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  3. Bowen Chen
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  4. Bing Zhao
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  5. Xue-jiao Gao
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Contributions

Xue-jiao Gao and Yanhe Zhang conceived and designed the experiments. Yanhe Zhang, Yueqi Xu, and Bowen Chen carried out the experiments. Yanhe Zhang and Bing Zhao processed the data. Yanhe Zhang and Xue-jiao Gao wrote the paper. The final manuscript was read and approved by all authors.

Corresponding author

Correspondence to Xue-jiao Gao.

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Ethics Approval and Consent to Participate

All the animal experiments involved in this paper have been approved by the Animal Research Ethics Committee of Northeast Agricultural University (NAUMO-2020–0019).

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The authors declare no competing interests.

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Zhang, Y., Xu, Y., Chen, B. et al. Selenium Deficiency Promotes Oxidative Stress-Induced Mastitis via Activating the NF-κB and MAPK Pathways in Dairy Cow. Biol Trace Elem Res 200, 2716–2726 (2022). https://doi.org/10.1007/s12011-021-02882-0

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  • DOI: https://doi.org/10.1007/s12011-021-02882-0

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