Abstract
The obtaining of microcarriers for the cell culture and delivery is an urgent task of tissue engineering and regenerative medicine. The novel method of surface modification of alginate microcarriers in the form of microspheres with a diameter of 200–300 μm was developed. The described method consists in covalent crosslinking between collagen and surface of alginate microcarriers. It was shown that the method makes it possible to completely modify the surface of the alginate microcarrier, which can be used to improve the biological properties of the microcarrier. Such microcarriers with improved biological properties can be considered as effective systems for cell delivery and culture.
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Funding
This study was partly supported by the Grant of the President of the Russian Federation for Supporting Leading Scientific Schools of the Russian Federation, project no. NSh-2598.2020.7.
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Safonova, L.A., Bobrova, M.M., Efimov, A.E. et al. Surface Modification of Alginate Microcarriers for Improvement of Their Biological Properties. Dokl Biol Sci 499, 97–98 (2021). https://doi.org/10.1134/S0012496621040050
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DOI: https://doi.org/10.1134/S0012496621040050