Skip to main content
SpringerLink
Log in

In Vitro Effects of Different Resveratrol Concentrations on the Structural State of Mitochondrial Membranes Isolated from Pea Leaves

  • CELL BIOPHYSICS
  • Published:
Biophysics Aims and scope Submit manuscript

Abstract

In this study, the effects of different concentrations of antioxidant resveratrol on microviscosity of mitochondrial membranes isolated from pea leaves were investigated. It was shown that resveratrol in physiological (5 × 10–6 M) and ultralow (5 × 10–14 M) doses changed the microviscosity and altered the structure of the membrane lipid bilayer. This antioxidant is thought to affect the activity of membrane proteins due to altered structures of lipid molecules that surround them and, in turn, influence mitochondrial activity and function. No change was found in the range between physiological and ultralow doses, which is a “dead” zone. Moreover, resveratrol in physiological concentrations was found to shift thermally induced structural transition to the lower temperature region; therefore, it can interfere with the normal regulation of natural processes

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. A. L. Lehninger, Principles of Biochemistry (Worth, New York, 1982; Mir, Moscow, 1985), Vol. 1.

  2. S. Stael, A. G. Rocha, A. J. Robinson, et al., FEBS Lett. 585 (24), 3935 (2011).

    Article  Google Scholar 

  3. G. M. Dymshits, Priroda 6 (1042), 54 (2002).

    Google Scholar 

  4. M. W. Hameed, I. Juszczak, R. Bock, and J. T. van Dongen, Plant Methods 13, 112 (2017).

    Article  Google Scholar 

  5. S. Okada and A. Brennicke, Mol. Genet. Genomics 276 (1), 71 (2006).

    Article  Google Scholar 

  6. D. C. Wallace, Cell 163 (1), 33 (2015).

    Article  Google Scholar 

  7. M. Picard, B. S. McEwen, E. S. Epel, and C. Sandif, Front Neuroendocrinol. 49, 72 (2018).

    Article  Google Scholar 

  8. B. Dasgupta and J. Milbrandt, Proc. Natl. Acad. Sci. U. S. A. 104, 7217 (2007).

    Article  ADS  Google Scholar 

  9. M. Lagouge, C. Argmann, Z. Gerhart-Hines, et al., Cell 127, 1109 (2006).

    Article  Google Scholar 

  10. Z. Ungvari, N. Labinskyy, P. Mukhopadhyay, et al., Am. J. Physiol:. Heart. Circ. Physiol. 297, H1876 (2009).

    Google Scholar 

  11. S. Pervaiz, Leuk. Lymphoma 40 (5–6), 491 (2001).

  12. S. A. Aristarkhova, G. V. Arkhipova, E. B. Burlakova, et al., Dokl. Akad. Nauk SSSR 228, 215 (1976).

    Google Scholar 

  13. E. B. Burlakova and N. G. Khrapova, Russ. Chem. Rev. 54 (9), 907 (1985).

  14. E. B. Burlakova, in Chemical and Biological Kinetics: New Horizons (Khimiya, Moscow, 2005), Vol. 2, pp. 10–45.

    Book  Google Scholar 

  15. F. F. Niyazi, N. V. Kuvardin, and E. A. Fat’yanova, Nauka Obraz.: Novoe Vremya 1 (1), 65 (2014).

    Google Scholar 

  16. N. V. Kuvardin, in Proc. Int. Conf Current Problems in Chemical Science (Kursk State Tech. Univ., Kursk, 2009), pp. 122–125.

  17. V. I. Binyukov, S. F. Borunova, M. G. Gol’dfel’d, et al., Biokhimiya 36 (6), 1149 (1971).

    Google Scholar 

  18. A. M. Vasserman, A. L. Buchachenko, A. L. Kovarskii, and I. B. Neiman, Vysokomol. Soedin., Ser. A 10, 1930 (1968).

  19. A. N. Kusnetsov, Spin Probe Method (Nauka, Moscow, 1985) [in Russian].

    Google Scholar 

  20. H. Kuchling, Taschenbuch der Physik (Harry Deutsch Verlag, Frankfurt am Main, 1981; Mir, Moscow, 1983).

  21. D. Chapman, Q. Rev. Biophys. 8, 185 (1975).

    Article  Google Scholar 

  22. M. Shinitzky and M. Inbar, Biochim. Biophys. Acta, Biomembr. 433 (1), 133 (1976).

    Article  Google Scholar 

  23. R. Kh. Makasheva, Pea (Kolos, Leningrad, 1973) [in Russian].

    Google Scholar 

  24. E. B. Burlakova, Vestn. Rus. Akad. Nauk 64 (5), 425 (1994).

    Google Scholar 

  25. R. B. Gennis, Biomembranes: Molecular Structure and Function (Springer, New York, 1989; Mir, Moscow, 1997).

Download references

Author information

Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    N. Yu. Gerasimov, O. V. Nevrova, I. V. Zhigacheva & A. N. Goloshchapov

  2. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, 127276, Moscow, Russia

    I. P. Generozova

Authors
  1. N. Yu. Gerasimov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. V. Nevrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. V. Zhigacheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. P. Generozova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. N. Goloshchapov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. Yu. Gerasimov.

Additional information

Translated by A. Boutanaev

Abbreviations: EPR—electron paramagnetic resonance, Ea— activation energy.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gerasimov, N.Y., Nevrova, O.V., Zhigacheva, I.V. et al. In Vitro Effects of Different Resveratrol Concentrations on the Structural State of Mitochondrial Membranes Isolated from Pea Leaves. BIOPHYSICS 66, 415–419 (2021). https://doi.org/10.1134/S0006350921030052

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006350921030052

Search

Navigation