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Multifractal and Wavelet Analysis of Changes in the Structure of Patterns of Involuntary Oscillatory Hand Movements in Individuals with Parkinson’s Disease

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Abstract

Wavelet and multifractal analysis has shown that alterations in oscillatory activity accompanied by long-term correlations between successive values of these oscillations occur as a result of movement disorders in the structure of patterns of involuntary oscillatory hand movements that arise during motor task performance. These alterations cause a significant increase in the variation of the amplitude of involuntary oscillatory hand movements in an individual with Parkinson’s disease compared to healthy individuals. The mechanism of the appearance of correlated dynamics is associated with an increase in the contribution of strong fluctuations of successive values of involuntary oscillations. A decrease in the variation of the amplitude of these oscillations and the energy of their wavelet spectrum in association with antiparkinsonian drugs is accompanied by a decrease in long-term correlations; multifractal characteristics tend to be attributed to the range that is characteristic of healthy individuals.

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ACKNOWLEDGMENTS

The author is grateful to Z.A. Aleksanyan, neurophysiologist (Bekhtereva Institute of Human Brain of the Russian Academy of Sciences) for providing experimental data.

Funding

The work was supported by the Program of Basic Research of State Academies for 2013–2020 (project no. GP-14, section 46).

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Correspondence to O. E. Dik.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of humans or animals. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by E. V. Makeeva

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Dik, O.E. Multifractal and Wavelet Analysis of Changes in the Structure of Patterns of Involuntary Oscillatory Hand Movements in Individuals with Parkinson’s Disease. BIOPHYSICS 66, 508–514 (2021). https://doi.org/10.1134/S0006350921030040

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  • DOI: https://doi.org/10.1134/S0006350921030040

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