Double knockout of vitamin D receptor and its coactivator mediator complex subunit 1 unexpectedly enhances epidermal permeability barrier function in mice

https://doi.org/10.1016/j.bbamcr.2021.119131Get rights and content
Under an Elsevier user license
open archive

Highlights

  • •

    Combined loss of VDR and Med1 improves epidermal barrier integrity.

  • •

    DKO mice show increased differentiation, ceramide & cornified envelope formation.

  • •

    A complex coordinate regulation of VDR and Med1 exists in keratinocyte.

Keywords

Differentiation
Lipid synthesis
Mediator complex subunit 1
Permeability barrier function
Vitamin d receptor

Cited by (0)

© 2021 Elsevier B.V.