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Molecular and Functional Heterogeneity of Na,K-ATPase in the Skeletal Muscle

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Abstract

Na,K-ATPase activity is critical for maintaining electrogenesis, contractile function and skeletal muscle performance. This review is devoted to the analysis of the results of recent studies in the field of molecular and functional diversity of Na,K-ATPase in skeletal muscles, which co-express α1 and α2 isoforms of the catalytic and transport Na,K-ATPase α subunit. The issues that seem to be most promising in terms of their further development are considered. The available facts indicate that, in contrast to the α1 isoform that demonstrates functional stability, the α2 isoform is distinguished by a high degree of plasticity, which is due to its specific membrane localization, functional and molecular interactions with the protein and lipid environment, as well as the peculiarities of its regulation by various factors. Functional disorders of the Na,K-ATPase α2 isoform are among the most common signs characteristic of both chronic and short-term forms of motor dysfunction.

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This work was supported by the Russian Science Foundation, grant no. 18-15-00043.

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    V. V. Kravtsova & I. I. Krivoi

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Translated by A. Polyanovsky

Russian Text © The Author(s), 2021, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2021, Vol. 107, Nos. 6–7, pp. 695–716https://doi.org/10.31857/S0869813921060066.

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Kravtsova, V.V., Krivoi, I.I. Molecular and Functional Heterogeneity of Na,K-ATPase in the Skeletal Muscle. J Evol Biochem Phys 57, 835–851 (2021). https://doi.org/10.1134/S0022093021040086

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