Immunity
Volume 54, Issue 9, 14 September 2021, Pages 1912-1914
Journal home page for Immunity

Preview
Illuminating the Fc dependence of SARS-CoV-2 neutralization

https://doi.org/10.1016/j.immuni.2021.08.024Get rights and content
Under an Elsevier user license
open archive

Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus and use bioluminescence imaging to longitudinally monitor infection and assess neutralizing monoclonal antibody interventions in mice. They find that antibody-mediated protection depends on the Fc domain and Fc-gamma receptor-expressing immune cells.

Cited by (0)