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Synthesis, Structure Elucidation, and Pharmacological Study of New Hydrazinylidene Derivatives Using Benzimidazole as a Scaffold

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Abstract

New hydrazinylidene derivatives were synthesized under appropriate conditions and in excellent yields, by the reaction between a new [1,3]thiazolo[3,2-a]benzimidazol-2(3H)-one substrate and a series of aryldiazonium salts bearing groups with different electronic effect. The structures of the synthesized compounds were verified by FT-IR, 1H NMR and mass spectra. The pharmacological study including determining antimicrobial activity, cytotoxicity LD50 and histological study for compound ethyl 4-[(2Z)-2-(2-oxo[1,3]thiazolo[3,2-a] benzimidazol-3(2H)-ylidene)hydrazinyl]benzoate have been fulfilled. All chemical and biological result show possibility of using the compound ethyl 4-[(2Z)-2-(2-oxo[1,3]thiazolo[3,2-a] benzimidazol-3(2H)-ylidene)hydrazinyl]benzoate as a new topical antibiotic.

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ACKNOWLEDGMENTS

The author is grateful to Zainb K. Mj for providing laboratory facilities in spectral analysis of the compounds. We also thank the Iraqi Center for Genetics and Cancer Research for providing facilities for this work.

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Authors and Affiliations

  1. Wasit University, Department of Chemistry, College of Science, 14022, Baghdad, Iraq

    K. R. Al-Jorani

  2. Mustansiriyah University, Department of Chemistry, College of Science, 10045, Baghdad, Iraq

    A. J. K. Atia & R. I. Al-Bayti

Authors
  1. K. R. Al-Jorani
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  2. A. J. K. Atia
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  3. R. I. Al-Bayti
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Corresponding author

Correspondence to K. R. Al-Jorani.

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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The authors declare that they have no conflict of interest.

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Al-Jorani, K.R., Atia, A.J. & Al-Bayti, R.I. Synthesis, Structure Elucidation, and Pharmacological Study of New Hydrazinylidene Derivatives Using Benzimidazole as a Scaffold. Russ J Bioorg Chem 47, 945–953 (2021). https://doi.org/10.1134/S1068162021040026

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