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Synthesis, Molecular Docking, and In Vitro Antibacterial Activities of Some Novel Aminobenzylnaphthol Derivatives via One-Pot Three-Component Reaction

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Abstract

This work provides the first example of incorporating the thiazole moiety into the aminobenzylnaphthol i.e. Betti base. A series of novel synthesized Betti bases via a one-pot three-component reaction of 2-amino-5-methyl thiazole, 2-naphthol, and substituted aldehydes are reported. The formation of desired products was confirmed using various spectroscopic techniques. The derivatives were screened in vitro for antibacterial activities. Molecular docking was also performed to predict the possible mode of action of these derivatives. The docking analysis ascertained that these derivatives regulate the antimicrobial potential via inhibition of DNA gyrase.

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ACKNOWLEDGMENTS

The authors are grateful to the Department of Chemistry, University of Mumbai, Santacruz (E.) for spectral analysis, Bharati Vidyapeeth College of Pharmacy, Kolhapur for computational studies.

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Authors and Affiliations

  1. Department of Chemistry, Bhavan’s H. Somani College, 400007, Mumbai, Chowpatty, India

    Shweta N. Dandekar, Onkar A. Lotlikar & Shrimant V. Rathod

  2. Department of Chemistry, University of Mumbai, 400098, Mumbai, Santacruz (E), India

    M. M. V. Ramana

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  1. Shweta N. Dandekar
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  2. Onkar A. Lotlikar
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  3. M. M. V. Ramana
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  4. Shrimant V. Rathod
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Correspondence to Shrimant V. Rathod.

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Statement on the welfare of humans or animals. This article does not contain any studies involving animals performed by any of the authors.

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The online version contains supplementary material available at https://doi.org/10.1134/S1068162021040075.

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Dandekar, S.N., Lotlikar, O.A., Ramana, M.M. et al. Synthesis, Molecular Docking, and In Vitro Antibacterial Activities of Some Novel Aminobenzylnaphthol Derivatives via One-Pot Three-Component Reaction. Russ J Bioorg Chem 47, 874–881 (2021). https://doi.org/10.1134/S1068162021040075

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