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Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs

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Abstract

One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200–1000 nucleotides. It is involved in important processes such as cell proliferation, regeneration and apoptosis; today it is used as a prognostic and diagnostic factor. A, various drugs by acting on lncRNAs can affect cells. Therefore, by accurately identifying IncRNAs function, we can play an effective role in preventing the development of cardiotoxicity-induced chemotherapy drugs, and use them as a therapeutic strategy to improve clinical symptoms and increase patient survival.

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Acknowledgements

We wish to thank all our colleagues in Shiraz University of Medical Sciences.

Author information

Authors and Affiliations

  1. High Institute for Education and Research in Transfusion Medicine, Tehran, Iran

    Mehran Amrovani

  2. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mohammadjavad Mohammadtaghizadeh

  3. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

    Mahsa Karimzadeh Aghaali

  4. Departement of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Somayeh Zamanifard

  5. Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Arash Alqasi

  6. Student Research Committee, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Mozhdeh Sanei

Authors
  1. Mehran Amrovani
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  2. Mohammadjavad Mohammadtaghizadeh
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  3. Mahsa Karimzadeh Aghaali
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  4. Somayeh Zamanifard
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  5. Arash Alqasi
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  6. Mozhdeh Sanei
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Contributions

MS has conceived the manuscript and revised it. MA and MM wrote the manuscript. MKA and AA design the tables.

Corresponding author

Correspondence to Mozhdeh Sanei.

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This article does not contain any studies with human participants or animals.

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Amrovani, M., Mohammadtaghizadeh, M., Aghaali, M.K. et al. Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs. Cardiovasc Toxicol 22, 191–206 (2022). https://doi.org/10.1007/s12012-021-09681-y

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  • DOI: https://doi.org/10.1007/s12012-021-09681-y

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