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Focused ultrasound: growth potential and future directions in neurosurgery

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Abstract

Over the past two decades, vast improvements in focused ultrasound (FUS) technology have made the therapy an exciting addition to the neurosurgical armamentarium. In this time period, FUS has gained US Food and Drug Administration (FDA) approval for the treatment of two neurological disorders, and ongoing efforts seek to expand the lesion profile that is amenable to ultrasonic intervention. In the following review, we highlight future applications for FUS therapy and compare its potential role against established technologies, including deep brain stimulation and stereotactic radiosurgery. Particular attention is paid to tissue ablation, blood–brain-barrier opening, and gene therapy. We also address technical and infrastructural challenges involved with FUS use and summarize the hurdles that must be overcome before FUS becomes widely accepted in the neurosurgical community.

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Funding

No funding was received for the production of this study. MZ receives research funding from the National Institutes of Health (5T32CA009695-27, MPI). GL receives research support from Bristol Myers Squibb, Novocure, and the National Institutes of Health.

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Authors and Affiliations

  1. Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

    Michael Zhang, Adrian Rodrigues, Quan Zhou & Gordon Li

  2. Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA

    Quan Zhou

  3. Center for Academic Medicine, Neurosurgery, Stanford University School of Medicine, MC 5327, 453 Quarry Road, Palo Alto, CA, 94304, USA

    Michael Zhang

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  1. Michael Zhang
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  2. Adrian Rodrigues
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  3. Quan Zhou
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  4. Gordon Li
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Contributions

Conceptualization: MZ, GL. Methodology: MZ, AJR, GL. Writing—original draft preparation: MZ, AJR, QZ. Writing—review and editing: MZ, AJR, QZ, GL. Funding acquisition: Not applicable. Resources: Not applicable. Supervision: GL.

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Correspondence to Michael Zhang.

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Conflict of interest

GL is a consultant for Medtronic, a speaker for DePuy Synthes/Johnson & Johnson, and owns stock in Abbott, Biogen, BioMarin Pharmaceutical, Inc., Bristol Myers Squibb, Exact Sciences, GlaxoSmithKline, Gilead Sciences, Inc., Merck & Co., Pfizer, and Stryker.

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Zhang, M., Rodrigues, A., Zhou, Q. et al. Focused ultrasound: growth potential and future directions in neurosurgery. J Neurooncol 156, 23–32 (2022). https://doi.org/10.1007/s11060-021-03820-9

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  • DOI: https://doi.org/10.1007/s11060-021-03820-9

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