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Intriguing new faces of Covid-19: persisting clinical symptoms and cardiac effects in children

Part of: Covid-19 Infectious

Published online by Cambridge University Press:  19 August 2021

Nurdan Erol Open the ORCID record for Nurdan Erol [Opens in a new window] ,
Abdullah Alpinar ,
Cigdem Erol ,
Erdal Sari  and
Kubra Alkan
Nurdan Erol*
Affiliation:
Health Sciences University, Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Uskudar, Istanbul 34668, Turkey
Abdullah Alpinar
Affiliation:
Health Sciences University, Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Uskudar, Istanbul 34668, Turkey
Cigdem Erol
Affiliation:
Istanbul University Informatics Department, Beyazit, Fatih, Istanbul 34452, Turkey
Erdal Sari
Affiliation:
Health Sciences University, Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Uskudar, Istanbul 34668, Turkey
Kubra Alkan
Affiliation:
Health Sciences University, Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Uskudar, Istanbul 34668, Turkey
*
Author for correspondence: N. Erol, Health Sciences University Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Pediatric Clinics, Dr. Burhanettin Ustunel Sokagi No:10, Uskudar, Istanbul 34668, Turkey. Tel: +902163910680; Fax: +902163910690. E-mail: nurdaneroltr61@gmail.com
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Abstract

Objective:

This study was conducted to evaluate the persisting Covid-19-related symptoms of the cases included in our study and to assess their cardiac findings to determine the impact of Covid-19 on children’s cardiovascular health.

Methods:

In this study, 121 children between the ages of 0– and 18 with Covid-19 were evaluated based on their history, blood pressure values, and electrocardiography and echocardiography results. These findings were compared with the findings of the control group which consisted of 95 healthy cases who were in the same age range as the study group and did not have Covid-19. The results were evaluated using the statistics program, SPSS 21.

Results:

There was no significant difference between the study group and the control group in terms of age, weight, and body mass index. The clinical symptoms (chest and back pain, dizziness, headache, palpitation, fatigue, shortness of breath, loss of balance, coughing) of 37.2% of the cases persisted for at least 1 month after Covid-19 recovery. Statistically significant differences were found in systolic blood pressure, left ventricular ejection fraction, relative wall thickness, and tricuspid annular plane systolic excursion.

Conclusion:

The continuation of some cases’ clinical symptoms post-recovery indicates that long Covid infection can be observed in children. The fact that statistically significant differences were observed between the echocardiographic parameters of the study and control groups suggests that Covid-19 may have effects on the cardiovascular system. To shed light on the long Covid cases among children and the infection’s cardiac impacts, it would be beneficial to conduct more comprehensive studies on this matter.

Keywords

Covid-19long Covidechocardiographymyocarditiscardiac involvementsystolic blood pressure
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 7 , July 2022 , pp. 1085 - 1091
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

Badal, S, Bajgain, KT, Badal, S, et al. Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: a systematic review and meta-analysis. J Clin Virol 2020; 135: 104715.CrossRefGoogle ScholarPubMed
Mohamadian, M, Chiti, H, Shoghli, A, et al. COVID-19: virology, biology and novel laboratory diagnosis. J Gene Med 2021; 23: e3303.CrossRefGoogle ScholarPubMed
Pousa, PA, Mendonc, TSC, Oliveira, EA, et al. Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations. J Pediat 2021; 97: 116–139.CrossRefGoogle ScholarPubMed
Ludvigsson, JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatrica 2020; 109: 1088–1095.CrossRefGoogle Scholar
Joshi, K, Kaplan, D, Bakar, A, et al. Cardiac dysfunction and shock in pediatric patients with COVID-19. Am Coll Cardiol Case Rep 2020; 2: 1267–1270.Google ScholarPubMed
Sperotto, F, Friedman, KG, Son, MBF, et al. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach. Eur J Pediatr 2021; 180: 307–322.CrossRefGoogle ScholarPubMed
Alsohimea, F, Temsaha, MH, Al-Nemri, AM, et al. COVID-19 infection prevalence in pediatric population: etiology,clinical presentation, and outcome. J Infect Public Heal 2020; 13: 1791–1717.Google Scholar
Huang, C, Huang, L, Wang, Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study lancet 2021, 397:220–232.CrossRefGoogle Scholar
Yong, SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors,and treatments. Infect Dis 2021, 1–18. DOI 10.1080/23744235.2021.1924397.Google ScholarPubMed
Carfì, A, Bernabei, R, Landi, F. Persistent symptoms in patients after acuteCOVID-19. JAMA 2020; 324: 603–605.CrossRefGoogle Scholar
Buonsenso, D, Munblit, D, De Rose, C, et al. Preliminary evidence on long COVID in children acta paediatrica 2021, 1–4.CrossRefGoogle Scholar
Harikrishnan, S, Mohanan, PP, Chopra, VK, et al. Cardiological society of India position statement on COVID-19 and heart failure. Indian Heart J 2020; 72: 75–81.CrossRefGoogle ScholarPubMed
Kwenandar, F, Japar, KV, Damay, V, et al. Coronavirus disease 2019 and cardiovascular system: a narrative review. IJC HeartVasculature 2020; 29, 100557.Google ScholarPubMed
Walsh, MN, Sorgente, A, Fischman, DL, et al. The COVID-19 pandemic and cardiovascular complications. What have we learned so far? J am Coll Cardiol Case Rep 2020; 2: 1235–1239.Google ScholarPubMed
. Coronavirus disease 2019 and the cardiovascular system: impacts and implications. Editorial. Indian Heart J 2020; 72: 1–6.Google Scholar
Sanna, G, Serrau, G, Bassareo, PP, et al. Children’s heart and COVID-19: up-to-date evidence in the form of a systematic review. Eur J Pediatr 2020; 179: 1079–1087.CrossRefGoogle ScholarPubMed
Parcha, V, Booker, KS, Kalra, R, et al. A retrospective cohort study of 12,306 pediatric COVID‐19 patients in the United States. Nature Sci Rep 2021; 11: 10231. DOI 10.1038/s41598-021-89553-1.Google Scholar
Hyde, Z. COVID-19,children and schools: over looked and at risk. Med J Australia 2020; 213: 444–446.CrossRefGoogle Scholar
Osmanov, IM, Spiridonova, E, Bobkova, P, et al. Risk factors for long covid in previously hospitalised children using the ISARIC global follow-up protocol: a prospective cohort study. Eur Respir J in press. DOI: 10.1183/13993003.01341-2021. https://erj.ersjournals.com/content/erj/early/2021/06/10/13993003.01341-2021.full.pdf Google Scholar
Huang, L, Zhao, P, Tang, D, et al. Cardiac involvement in patients recovered from COVID-2019 identified using magnetic resonance imaging. J Am Coll Cardiol Img 2020; 13: 2330–2339.CrossRefGoogle ScholarPubMed
Moody, WE, Liu, B, Mahmoud-Elsayed, HM, et al. Persisting adverse ventricular remodeling in COVID-19 survivors: a longitudinal echocardiographic study. J Am Soc Echocardiog 2021; 34: 562–566.CrossRefGoogle ScholarPubMed
Buonsenso, D, Di Giuda, D, Sigfrid, L, et al. Evidence of lung perfusion defects and ongoing inflammation in an adolescent with post-acute sequelae of SARS-CoV-2 infection. Lancet Child Adolesc Health 2021; 5: 677–680. DOI 10.1016/S2352-4642(21)00196-6. Retrieved July 30, 2021.CrossRefGoogle Scholar
Matsubara, D, Kauffman, HL, Wang, Y, et al. Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States. J Am Coll Cardiol 2020; 76: 1947–1961.CrossRefGoogle ScholarPubMed
Wang, D, Hu, B, Hu, C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan. China JAMA 2020; 323: 1061–1069.CrossRefGoogle ScholarPubMed
Deng, Q, Hu, B, Zhang, Y, et al. Suspected myocardial injury in patients with COVID-19: evidence from front-line clinical observation in Wuhan. China Int J Cardiol 2020; 311: 116–121.CrossRefGoogle ScholarPubMed
Huang, C, WangY, Li, etal, X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet 2020; 395: 497–506.CrossRefGoogle ScholarPubMed
Dufort, EM, Koumans, EH, Chow, EJ, et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med 2020; 383: 347–358.CrossRefGoogle ScholarPubMed
Goldstein, DS. The possible association between COVID-19 and postural tachycardia syndrome. Heart Rhythm 2021; 18: 508–509.CrossRefGoogle ScholarPubMed