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ARTIFICIAL METALLOENZYMES

Striking gold with chimeric proteins

The ability to control the subtle differences in reaction mechanisms and outcomes is an aspiration of many synthetic chemists. Now protein evolution has enabled the control of selectivity for hydroamination reactions catalysed by gold-based artificial metalloenzymes by favouring dual-gold catalysis over monomeric catalysis.

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Fig. 1: The design and optimization of chimeric Sav-SOD proteins for selective gold catalysis.

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Correspondence to Amanda G. Jarvis.

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Jarvis, A.G. Striking gold with chimeric proteins. Nat Catal 4, 639–640 (2021). https://doi.org/10.1038/s41929-021-00664-4

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