Skip to main content
Log in

Analytical chemistry reveals secrets of alchemy

  • Review
  • Published:
Monatshefte für Chemie - Chemical Monthly Aims and scope Submit manuscript

Abstract

The review collects papers on the application of analytical chemistry in revealing the history of alchemy. In addition to historical alchemical texts, preserved material remains can also be a valuable source of information for historians of alchemy. The first part of the review focuses on the analysis of material artifacts: the remains of alleged transmutations (alchemical gold and silver), the rarely preserved specimens of Philosophers’ Stone, alchemical medicines, remains of alchemical vessels and laboratories (cupellation included), and analysis of the bodily remains of the alchemists themselves. Non-destructive spectrometric methods predominate in these analyses. Experimental reconstruction of the course and the results of old alchemical processes and their subsequent analysis is another way to reveal the history of alchemy. This approach, which has only been used in recent decades, is covered in the second part of the review. The published individual reconstructions are set in a chemical–historical context and arranged into three time periods: ancient and Arabian alchemy, medieval and renaissance alchemy, and late alchemy and chymistry. The review demonstrates that analytical chemistry is a very effective and potent technique for discovering new information about the history of alchemy.

Graphic abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Szabadváry F (1966) History of analytical chemistry. Pergamon Press, Oxford

    Google Scholar 

  2. Nummedal TE (2011) Isis 102:330

    Article  PubMed  Google Scholar 

  3. Martinón-Torres M (2011) Ambix 58:215

    Article  PubMed  Google Scholar 

  4. Crosland MP (1962) Historical studies in the language of chemistry. Harvard University Press, Cambridge

    Google Scholar 

  5. Principe LM (2013) The secrets of alchemy. The University of Chicago Press, Chicago

    Google Scholar 

  6. Newman WR, Principe LM (1998) Early Sci Med 3:32

    Article  CAS  PubMed  Google Scholar 

  7. Karpenko V (1992) Ambix 39:47

    Article  CAS  Google Scholar 

  8. Karpenko V (1988) Ambix 35:65

    Article  Google Scholar 

  9. Strebinger R, Reif W (1932) Die Mitteilungen der Österreichischen Numismatischen Gesellschaft 16:199

    Google Scholar 

  10. Carlström D, Lagerquist LO (1968) Nordisk numismatisk unions medlemsblad 41

  11. Berzelius JJ (1841) Lehrbuch der Chemie: Zehnter Band. Arnoldische Buchhandlung, Dresden

    Google Scholar 

  12. Karpenko V (2005) Dějiny věd a techniky 38:257

    Google Scholar 

  13. Pernicka E, Reichenberger A (2016) Eine angebliche Alchemistenmünze von Plötzkau. In: Meller H, Reichenberger A, Wunderlich CH (eds), Alchemie und Wissenschaft des 16. Jahrhunderts: Fallstudien aus Wittenberg und vergleichbare Befunde. Landesamt für Denkmalpflege und Archäologie Sachsen-Anhalt, Landesmuseum für Vorgeschichte, Halle

  14. Trimble RF (1980) J Chem Educ 57:645

    Article  CAS  Google Scholar 

  15. Kauffman GB (1983) Ambix 30:65

    Article  CAS  PubMed  Google Scholar 

  16. Kauffman GB (1988) Gold Bull 21:69

    Article  CAS  Google Scholar 

  17. Barbault A (1975) Gold of a thousand mornings. Neville Spearrnan, London

    Google Scholar 

  18. Giumlia-Mair A (2001) Surf Eng 17:217

    Article  CAS  Google Scholar 

  19. Giumlia-Mair A (1998) Arheološki vestnik 49:243

    Google Scholar 

  20. Keyser PT (1995/1996) Am J Numis 7/8:209

  21. Bottollier-Curtet H, Köberl O, Combarieu R, Biberian JP (2007) J Condensed Matter Nucl Sci 1:148

    Google Scholar 

  22. Wunderlich CH, Werthmann R (2016) Der Stein der Weisen des Esaias Stumpffeld — Alchemist im Dienste des Fürsten zu Stolberg-Wernigerode. In: Meller H, Reichenberger A, Wunderlich CH (eds), Alchemie und Wissenschaft des 16. Jahrhunderts: Fallstudien aus Wittenberg und vergleichbare Befunde. Landesamt für Denkmalpflege und Archäologie Sachsen-Anhalt, Landesmuseum für Vorgeschichte, Halle

  23. Werthmann R (2016) Experimentelle Alchemie — Die Gothaer Proben vom “Stein der Weisen”. In: Meller H, Reichenberger A, Wunderlich CH (eds) Alchemie und Wissenschaft des 16. Jahrhunderts: Fallstudien aus Wittenberg und vergleichbare Befunde. Landesamt für Denkmalpflege und Archäologie Sachsen-Anhalt, Landesmuseum für Vorgeschichte, Halle

  24. Nesměrák K, Kudláček K, Babica J (2017) Monatsh Chem 148:1557

    Article  CAS  Google Scholar 

  25. Console R (2013) Pharmaceutical use of gold from antiquity to the seventeenth century. In: Duffin CJ, Moody RTJ, Gardner-Thorpe C (eds) A history of geology and medicine. The Geological Society, London

  26. Charlier P, Poupon J, Huynh-Charlier I, Saliège JF, Favier D, Keyser C, Ludes B (2009) BMJ 339:1402

    Article  Google Scholar 

  27. Anderson RGW (2000) The archaeology of chemistry. In: Holmes FL, Levere TH (eds), Instruments and experimentation in the history of chemistry. The MIT Press, Cambridge

  28. Kamber P, Kurzmann P (1998) Der Gelbschmied und Alchemist(?) vom Ringelhof. In: Jahresbericht der Archäologischen Bodenforschung Basel-Stadt. Archäologische Bodenforschung des Kantons Basel-Stadt, Basel

  29. Moorhouse S, Greenaway F, Moore CC, Bellamy CV, Nicolson WE, Biek L (1972) Mediev Archaeol 16:79

    Article  Google Scholar 

  30. von Osten S (1998) Das Alchemistenlahoratorium von Oberstockstall. Ein Fundkomplex des 16. Jahrhunderts aus Niederösteireich. Universitätsverlag Wagner, Innsbruck

  31. Soukup RW (2007) Crucibles, cupels, cucurbits: recent results of research on Paracelsian alchemy in Austria around 1600. In: Principe LM (ed), Chymists and chymistry: Studies in the history of alchemy and early modem chemistry. Watson Publishing International, Sagamore Beach

  32. Soukup RW, Mayer H (1997) Alchemistisches Gold, Paracelsistische Pharmaka: Laboratoriumstechnik im 16. Jahrhundert. Böhlau, Wien

  33. Veronesi U, Martinón-Torres M (2018) Angew Chem Int Ed 57:7346

    Article  CAS  Google Scholar 

  34. Reichenberger A (2016) Der Alchemiefund aus dem Franziskanerkloster in Wittenberg im Spannungsfeld zwischen Scharlatanerie und Wissenschaft. Eine Einführung. In: Meller H, Reichenberger A, Wunderlich CH (eds), Alchemie und Wissenschaft des 16. Jahrhunderts: Fallstudien aus Wittenberg und vergleichbare Befunde. Landesamt für Denkmalpflege und Archäologie Sachsen-Anhalt, Landesmuseum für Vorgeschichte, Halle

  35. Wunderlich CH (2016) Keine “Alchimei böser Buben“: Spagyrische Arzneiproduktion in Renaissance und Barock am Beispiel der Laborfunde von Wittenberg und Huysburg. In: Meller H, Reichenberger A, Wunderlich CH (eds), Alchemie und Wissenschaft des 16. Jahrhunderts: Fallstudien aus Wittenberg und vergleichbare Befunde. Landesamt für Denkmalpflege und Archäologie Sachsen-Anhalt, Landesmuseum für Vorgeschichte, Halle

  36. Spargo PE (2005) S Afr J Sci 101:315

    CAS  Google Scholar 

  37. Hull G (2003) Post-Medieval Archaeol 37:1

    Article  Google Scholar 

  38. Martinón-Torres M (2012) Ambix 59:22

    Article  PubMed  CAS  Google Scholar 

  39. Veronesi U, Rehren T, Martinón-Torres M (2021) J Archaeol Sci Rep 35:102684

    Google Scholar 

  40. Haynes ML, Baker F, Tipping R (1998) Post-Medieval Archaeol 32:33

    Article  Google Scholar 

  41. Bartolozzi G, Bracci S, Cantisani E, Iannaccone R, Magrini D, Picollo M (2020) Spectrochim Acta A 240:118562

    Article  CAS  Google Scholar 

  42. Rehren T (1996) Hist Metall 30:136

    Google Scholar 

  43. Newman WR (2000) Alchemy, assaying, and experiment. In: Holmes FL, Levere TH (eds), Instruments and experimentation in the history of chemistry. The MIT Press, Cambridge

  44. Newman WR, Principe LM (2002) Alchemy tried in the fire: Starkey, Boyle, and the fate of Helmontian chemistry. The University of Chicago Press, Chicago

    Book  Google Scholar 

  45. Martinón-Torres M, Rehren T (2009) Archaeometry 51:49

    Article  CAS  Google Scholar 

  46. Martinón-Torres M, Rehren T (2005) Hist Metall 39:14

    Google Scholar 

  47. Martinón-Torres M (2007) The tools of the chymist: archaeological and scientific analyses of early modern laboratories. In: Principe LM (ed), Chymists and chymistry: Studies in the history of alchemy and early modem chemistry. Watson Publishing International, Sagamore Beach

  48. Mongiatti A (2009) Assaying and smelting noble metals in sixteenth-century Austria: A comparative analytical study. University College London. https://discovery.ucl.ac.uk/id/eprint/18710/ Accessed 8 May 2021

  49. Spargo PE, Pounds CA (1979) Notes Rec R Soc Lond 34:11

    Article  CAS  PubMed  Google Scholar 

  50. Newman WR (2019) Newton the alchemist: science, enigma, and the quest for nature’s “secret fire.” Princeton University Press, Princeton

    Book  Google Scholar 

  51. Rasmussen KL, Kučera J, Skytte L, Kameník J, Havránek V, Smolík J, Velemínský P, Lynnerup N, Bruzek J, Vellev J (2013) Archaeometry 55:1187

    Article  CAS  Google Scholar 

  52. Kučera J, Rasmussen KL, Kameník J, Kubešová M, Skytte L, Povýšil C, Karpenko V, Havránek V, Velemínský P, Lynnerup N, Brůžek J, Smolík J, Vellev J (2017) Archaeometry 59:918

    Article  CAS  Google Scholar 

  53. Jonas L, Jaksch H, Zellmann E, Klemm KI, Andersen PH (2012) Ultrastruct Pathol 36:312

    Article  PubMed  Google Scholar 

  54. Mendelsohn JA (1992) Past Present 135:30

    Article  Google Scholar 

  55. Lenihan J (1988) The crumbs of creation: trace elements in history, medicine, industry, crime and folklore. CRC Press, Boca Raton

    Google Scholar 

  56. Mari F, Polettini A, Lippi D, Bertol E (2006) BMJ 333:1299

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Zilberstein G, Zilberstein S, Maor U, Baskin E, D’Amato A, Righetti PG (2019) Talanta 204:82

    Article  CAS  PubMed  Google Scholar 

  58. Usselman MC, Reinhart C, Foulser K, Rocke AJ (2005) Ann Sci 62:1

    Article  Google Scholar 

  59. Fors H, Principe LM, Sibum HO (2016) Ambix 63:85

    Article  PubMed  Google Scholar 

  60. Newman WR (1998) The place of alchemy in the current literature on experiment. In: Heidelberger M, Steinle F (eds), Experimental essays: Versuche zum Experiment. Nomos, Baden-Baden

  61. Reardon S (2011) Science 332:914

    Article  CAS  PubMed  Google Scholar 

  62. Principe LM (2018) Texts and practices: the promises and problems of laboratory replication and the chemical explanation of early alchemical processes. In: Nicolaidis E (ed), Greek alchemy from late antiquity to early modernity. Brepols, Turnhout

  63. Chalupa R, Nesměrák K (2018) Monatsh Chem 149:1527

    Article  CAS  Google Scholar 

  64. Chang H (2011) Sci Educ 20:317

    Article  Google Scholar 

  65. Exarchakos K, Skordoulis K (2018) The educational applications of the historical material and on the reproduction of alchemical procedures. In: Nicolaidis E (ed), Greek alchemy from late antiquity to early modernity. Brepols, Turnhout

  66. Chalupa R, Nesměrák K (2020) Monatsh Chem 151:1193

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Jacobson DM, McKenzie JS (1992) Interdiscip Sci Rev 17:326

    Article  Google Scholar 

  68. Jacobson DM (2000) Gold Bull 33:60

    Article  CAS  Google Scholar 

  69. Crabbé A, Vandendael I, Dewanckel G, Terryn H, Wouters HJM (2013) Surf Eng 29:159

    Article  CAS  Google Scholar 

  70. Ferrari E, Mercier F, Foy E, Téreygeol F (2021) J Archaeol Sci Reports 36:102742

    Article  Google Scholar 

  71. Martelli M (2009) Ambix 56:5

    Article  CAS  PubMed  Google Scholar 

  72. Schütt HW (2000) Auf der Suche nach dem Stein der Weisen. Beck, München

    Google Scholar 

  73. Moureau S, Thomas N (2016) Ambix 63:98

    Article  PubMed  Google Scholar 

  74. Martínez García MJ, Martínez Armero ME (2013) e-Preservation Sci 10:90

    Google Scholar 

  75. Ansaloni A, Occhipinti E (2012) Chim Ind (Rome, Italy) 94:118

  76. Rampling JM (2020) The experimental fire: inventing English alchemy, 1300–1700. The University of Chicago Press, Chicago

    Book  Google Scholar 

  77. Rodygin MY, Rodygin IV (1997) J Chem Educ 74:949

    Article  CAS  Google Scholar 

  78. Miguel C, Pinto JV, Clarke M, Melo MJ (2014) Dye Pigment 102:210

    Article  CAS  Google Scholar 

  79. Mousavi A (2019) Rev Inorg Chem 39:223

    Article  CAS  Google Scholar 

  80. Panzarasa G (2015) Bull Hist Chem 40:1

    CAS  Google Scholar 

  81. Epstein M, Garlaschelli L (1992) J Sci Explor 6:233

    Google Scholar 

  82. Palomar T, Díaz Hidalgo RJ, Vilarigues M (2018) Int J Appl Glas Sci 9:555

    Article  CAS  Google Scholar 

  83. Pearson J, Duckworth CN, López-Rider J, Govantes-Edwards D (2021) J Mediev Iber Stud 13:119

    Article  Google Scholar 

  84. Principe LM (1987) Ambix 34:21

    Article  CAS  PubMed  Google Scholar 

  85. Principe LM (2000) Apparatus and reproducibility in alchemy. In: Holmes FL, Levere TH (eds), Instruments and experimentation in the history of chemistry. The MIT Press, Cambridge

  86. Newman WR (2006) Atoms and alchemy : chymistry and the experimental origins of the scientific revolution. The University of Chicago Press, Chicago

    Book  Google Scholar 

  87. Starkey G (2004) Alchemical laboratory notebooks and correspondence. The University of Chicago Press, Chicago

    Book  Google Scholar 

  88. Hagendijk T, Vilarigues M, Dupré S (2020) Ambix 67:323

    Article  PubMed  Google Scholar 

  89. The Chymistry of Isaac Newton. www.chymistry.org. Accessed 8 May 2021

  90. Principe LM (2016) Ambix 63:118

    Article  PubMed  Google Scholar 

  91. Jensen WB (1989) Bull Hist Chem 3:21

    Google Scholar 

  92. Hendriksen MMA, Verwaal RE (2020) Ber Wissenschaftsgesch 43:385

    Article  Google Scholar 

  93. Newman WR, Principe LM (2005) Alchemy and the changing significance of analysis. In: Buchwald JZ, Franklin A (eds), Wrong for the right reasons. Springer, Dordrecht

Download references

Acknowledgements

The project Progress Q46 of Charles University is gratefully acknowledged for the financial support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Karel Nesměrák.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chalupa, R., Nesměrák, K. Analytical chemistry reveals secrets of alchemy. Monatsh Chem 152, 1019–1032 (2021). https://doi.org/10.1007/s00706-021-02813-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00706-021-02813-8

Keywords

Navigation