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Analysis of Medication Prescriptions for Hypertension in a Class 1 and Grade A Hospital in Shanxi Province

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Abstract

Introduction

This study aimed to examine the medication prescriptions for hypertension in a class 1 and grade A hospital in Shanxi province to provide references for clinical rational drug use.

Methods

An inpatient medical record inquiry system was used to evaluate the use of antihypertensives in a hypertensive population (age ≥ 18 years old) who received a prescription for one or more antihypertensives between January 2017 and December 2019. The hypertensive population was categorized into grades (1, 2, and 3), age groups, and different comorbidities to analyze the medication prescriptions. Drug analysis included angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor antagonist (ARB), calcium channel blocker (CCB), diuretics, and beta-receptor blockers (B-RB). SPSS16.0 was used for statistical analysis, including one-way analysis of variance (ANOVA,) chi-squared test, and multifactor logistic regression analysis.

Results

The overall control rate of blood pressure was 60.79%. The control rates of single, double, triple, and quadruple antihypertensives were 70.08%, 59.97%, 56.27%, and 45.23%, respectively. There were more cases of grade 3 than grades 1 and 2. The 18–65 years group was larger than the 66–79 years and ≥ 80 years groups. With the increase in grade, the prescription rate of the single drug decreased and the prescription rate of the combination drug increased, but this phenomenon was not obvious in different age groups. The most common drug prescribed for monotherapy was CCB; CCB combined with B-RB had the highest drug use in the double group by age or grade. Statistically significant differences were detected in the type of comorbidities between different age groups (P < 0.001), while only some differences were observed between different grades. Also, statistically significant differences were observed in the drugs prescribed for patients with hypertension with different comorbidities (P < 0.001). Factors influencing the efficiency of antihypertensives included sex, age, diabetes, heart failure, and usage of CCB and B-RB. The prescription rate of ARB combined with B-RB was relatively higher in grade 2 cases. B-RB was the primary drug for patients with diabetes, significantly increasing the blood glucose level.

Conclusions

The medication prescription of this hospital was in line with the requirements of China’s hypertension prevention and treatment guidelines. The pathophysiology of patients with hypertension in different age groups, increased use of combination drugs, and rational drug requirement should be considered when prescribing drugs.

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Acknowledgements

Funding

The authors funded the study and the Journal’s rapid service fee.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Zhen Li, Siyang Wang, Tingting Zhi, Hongxia Wang, Yuanyuan Zhu, Jian Ren, Yanhui Wang, Zhiqing Yao, Huizi Zhang, Jinxin Feng, and Ruiqing Zhang have nothing to disclose.

Authorship Contributions

Zhen Li: Conceptualization-Equal, Data curation-Equal, Formal analysis-Equal, Writing original draft-Supporting, Writing review and editing-Supporting. Siyang Wang: Conceptualization-Equal, Formal analysis-Equal, Investigation-Equal, Writing original draft-Lead, Writing, review & editing*Lead. Tingting Zhi: Data curation-Equal; Hongxia Wang: Data curation-Equal; Jian Ren: Data curation-Equal, Writing original; Yuanyuan Zhu: Formal analysis-Equal, Supervision-Equal; Yanhui Wang: Data curation-Equal, Formal analysis-Equal; Zhiqing Yao: Data curation-Equal, Formal analysis-Equal; Huizi Zhang: Data curation-Equal; Jinxin Feng: Data curation-Equal;Ruiqin Zhang: Conceptualization-Equal, Formal analysis-Equal, Writing review & editing-Supporting.

Compliance with Ethics Guidelines

This study was performed in accordance with the Helsinki Declaration of 1964 and its later amendments and approved by the ethics committee of The Second Hospital of Shanxi Medical University with waiver of informed consent. Approval No. (2020) XY No. (170).

Data Availability

All data generated or analyzed during this study are included in this published article.

Author information

Authors and Affiliations

  1. Shanxi Medical University, Taiyuan, Shanxi, China

    Zhen Li, Yanhui Wang, Zhiqing Yao, Huizi Zhang & Jinxin Feng

  2. The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

    Siyang Wang, Jian Ren, Tingting Zhi, Hongxia Wang, Yuanyuan Zhu & Ruiqing Zhang

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  1. Zhen Li
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Correspondence to Ruiqing Zhang.

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Li, Z., Wang, S., Ren, J. et al. Analysis of Medication Prescriptions for Hypertension in a Class 1 and Grade A Hospital in Shanxi Province. Adv Ther 38, 5100–5115 (2021). https://doi.org/10.1007/s12325-021-01869-6

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