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Astrocytic modulation on neuronal electric mode selection induced by magnetic field effect

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Abstract

Astrocytes as well as electromagnetic induction have been primarily considered as main factors in regulating neuronal firing patterns in the recent decade. In this work, an improved neuron-astrocyte model in consideration of the modulation of astrocytes and the electromagnetic induction is employed to explore the extend to which both of the factors affect the firing modes of the neurons. The “alternation mode”, defined as the alternative of neural normal spiking mode with the high-frequency bursting-like mode, clearly shows the functions of astrocytes on neurons. Moreover, the firing pattern of the neuron becomes more abnormal when astrocytes are hyper-excitable, the reason why the abnormal coupling of the astrocyte leads to the “alternation mode” of the neuron have been studied. In addition, the effect of electromagnetic induction manifests nonlinear characteristic towards neurons, complex firing modes of neurons are observed in the weaker field and a switching mode consists with quiescent and spiking mode appears when there is a higher stronger field. This approved model can reveal the normal or abnormal electric activities of neuron considered electromagnetic induction induced by the degree of excitability of the astrocyte. These results can provide potential understanding about the effects of astrocyte on neuronal activity when the coupling of electromagnetic field is considered.

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Authors and Affiliations

  1. State Key Laboratory for Strength and Vibration of Mechanical Structures, Shaanxi Engineering Laboratory for Vibration Control of Aerospace Structures, School of Aerospace Engineering, Xian Jiaotong University, Xian, 710049, China

    Zhixuan Yuan, Peihua Feng, Yongchen Fan, Yangyang Yu & Ying Wu

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  1. Zhixuan Yuan
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  2. Peihua Feng
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  3. Yongchen Fan
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  4. Yangyang Yu
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  5. Ying Wu
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Correspondence to Ying Wu.

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Project supported by the National Natural Science Foundation of China (Grant No. 11272242 and Grant No. 11972275) and China Postdoctoral Science Foundation (Grant No. 2018M631140).

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Yuan, Z., Feng, P., Fan, Y. et al. Astrocytic modulation on neuronal electric mode selection induced by magnetic field effect. Cogn Neurodyn 16, 183–194 (2022). https://doi.org/10.1007/s11571-021-09709-7

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  • DOI: https://doi.org/10.1007/s11571-021-09709-7

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