Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Genome Watch
  • Published:

An uneven race: genome editing for parasitic worms

This month’s Genome Watch highlights recent advances in genome editing of parasitic worms that affect one-fifth of humans globally.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Gang, S. S. et al. Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog. 13, e1006675 (2017).

    Article  Google Scholar 

  2. Liu, C., Grote, A., Ghedin, E. & Unnasch, T. R. CRISPR-mediated transfection of Brugia malayi. PLoS Negl. Trop. Dis. 14, e0008627 (2020).

    Article  CAS  Google Scholar 

  3. Arunsan, P. et al. Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity. eLife 8, e41463 (2019).

    Article  Google Scholar 

  4. Ittiprasert, W. et al. Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni. eLife 8, e41337 (2019).

    Article  Google Scholar 

  5. Sankaranarayanan, G. et al. Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni. Wellcome Open Res. 5, 178 (2021).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gabriel Rinaldi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sankaranarayanan, G., Berriman, M. & Rinaldi, G. An uneven race: genome editing for parasitic worms. Nat Rev Microbiol 19, 621 (2021). https://doi.org/10.1038/s41579-021-00625-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41579-021-00625-5

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing