This month’s Genome Watch highlights recent advances in genome editing of parasitic worms that affect one-fifth of humans globally.
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References
Gang, S. S. et al. Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog. 13, e1006675 (2017).
Liu, C., Grote, A., Ghedin, E. & Unnasch, T. R. CRISPR-mediated transfection of Brugia malayi. PLoS Negl. Trop. Dis. 14, e0008627 (2020).
Arunsan, P. et al. Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity. eLife 8, e41463 (2019).
Ittiprasert, W. et al. Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni. eLife 8, e41337 (2019).
Sankaranarayanan, G. et al. Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni. Wellcome Open Res. 5, 178 (2021).
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Sankaranarayanan, G., Berriman, M. & Rinaldi, G. An uneven race: genome editing for parasitic worms. Nat Rev Microbiol 19, 621 (2021). https://doi.org/10.1038/s41579-021-00625-5
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DOI: https://doi.org/10.1038/s41579-021-00625-5
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Transgenesis in parasitic helminths: a brief history and prospects for the future
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