Correlation of blood high mobility group box-1 protein with mortality of patients with sepsis: A meta-analysis
Section snippets
Background
Sepsis, defined as a life-threatening organ dysfunction attributable to a dysregulated host response to infection,1 remains a major cause of death in the intensive care unit (ICU) and a critical consumer for medical resources around the world, along with its associated illnesses. According to a global study, there were an estimated 11.0 million incident cases of sepsis-related mortality worldwide in 2017, representing about 19.7% of all global deaths.2 To promptly identify sepsis patients at
Materials and methods
We conducted the study following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statements. 8
Study selection
A total of 2461 studies were yielded from six electronic databases and manual search, of which 65 potentially relevant papers were under assessment for eligibility following removing records according to titles and abstracts. After full-text evaluation, there were 18 studies finally used to meta-analyze.4,6,7,13., 14., 15., 16., 17., 18., 19., 20., 21., 22., 23., 24., 25., 26., 27. Detail regarding the process of study selection is shown in Fig. 1.
Study characteristics and quality
A total of 1163 patients with sepsis from nine
Discussion
Sepsis remains a significant, serious, and heterogeneous health problem that is difficult to be defined accurately, associated with high mortality rates worldwide. The detection and measurement of biomarkers, which are easy to handle in day-to-day clinical settings, currently have been taken as not only diagnostic tools in the face of suspected sepsis but also prognostic indicators at the diagnosis of sepsis. This meta-analysis was here to investigate the association of HMGB-1, a novel
Declaration of Competing Interest
None declared.
Acknowledgments
None declared.
Financial disclosure
None declared.
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