Abstract
Neuroinflammation is one of the host defensive mechanisms through which the nervous system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation occurs as one of the most common pathological outcomes in various neurological disorders, makes it the promising target. The present review focuses on elaborating the recent advancement in understanding molecular mechanisms of neuroinflammation and its role in the etiopathogenesis of various neurological disorders, especially Alzheimer’s disease (AD), Parkinson’s disease (PD), and Epilepsy. Furthermore, the current status of anti-inflammatory agents in neurological diseases has been summarized in light of different preclinical and clinical studies. Finally, possible limitations and future directions for the effective use of anti-inflammatory agents in neurological disorders have been discussed.
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References
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The authors would like to acknowledge the Head of School, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara for the necessary infrastructure and facility. The figures in the manuscript are "Created by BioRender.com".
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AM: Concept designing, execution, data collection, interpretation, writing; RB: Data collection; PKS: Data Collection; PSM: Data collection and conceptualizing figures; NS: Prrof reading, language editing; NK: Proof reading, language editing; All authors read and approved the final manuscript.
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Mishra, A., Bandopadhyay, R., Singh, P.K. et al. Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside. Metab Brain Dis 36, 1591–1626 (2021). https://doi.org/10.1007/s11011-021-00806-4
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DOI: https://doi.org/10.1007/s11011-021-00806-4