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Size dependent mechanistic activity of titanium dioxide nanoparticles for enhanced fibroblast cell proliferation and anti-bacterial activity

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

Many biomedical applications, titanium dioxide (TiO2) nanoparticles are used. They have been used for drugs delivery and targeting, skin tone protection, reinforcement materials etc. It is biocompatible and non-toxic in nature. The healing of wounds are delayed mainly due to infections. Infections make the process of wound healing complex. Nanomaterials are used for enhancing wound healing mainly due to their ability to inhibit bacterial growth. Nanoparticles of TiO2 are synthesized using a chemical method. They are annealed at different temperature to increase the particle size. XRD (X-ray diffraction), FTIR (Fourier Transform infrared spectroscopy), and TEM (Transmission electron Microscopy) are used to classify the samples. The influence of particle size and phase transformation on fibroblast cell proliferation. F-actin, cell movement are analysed. It is found that the antimicrobial activity increases with decrease in particle size. This study confirms the utilization of TiO2 nanoparticles for wound healing applications.

Highlights

  • Influence of particle size on Fibroblast growth is analyzed.

  • Influence of particle size on antimicrobial activity is analyzed.

  • The role of F-actin is imaged.

  • Cell migration studies confirms enhanced wound healing.

  • Staining studies confirms the cell proliferation.

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Acknowledgements

We thank to Department of Nanotechnology, SRM Institute of Science and Technology for providing the facility to carry out the work.

Author contributions

KSV and JP: Methodology, Validation, Investigation, Visualization, Writing—original draft. TA: Investigation, Validation. GDV: Conceptualization, Supervision, Validation, Writing—review & editing.

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Author notes

  1. These authors contributed equally: K.S. Venkataprasanna J. Prakash

Authors and Affiliations

  1. Department of Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram Dist, Tamil Nadu, India

    K. S. Venkataprasanna, J. Prakash & G. Devanand Venkatasubbu

  2. Department of Physics, Indian Institute of Information Technology Design & Manufacturing, Kancheepuram, Chennai, 600127, India

    T. Anusuya

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  1. K. S. Venkataprasanna
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  2. J. Prakash
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Correspondence to G. Devanand Venkatasubbu.

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Venkataprasanna, K.S., Prakash, J., Anusuya, T. et al. Size dependent mechanistic activity of titanium dioxide nanoparticles for enhanced fibroblast cell proliferation and anti-bacterial activity. J Sol-Gel Sci Technol 99, 565–575 (2021). https://doi.org/10.1007/s10971-021-05600-3

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  • DOI: https://doi.org/10.1007/s10971-021-05600-3

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