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RIBOSOMES

Mitoribosome assembly comes into view

Nature Structural & Molecular Biology volume 28, pages 631–633 (2021)Cite this article

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The folding of ribosomal RNAs is central to the biogenesis of the mitoribosome and is a complex, stepwise process. Five recent cryo-EM studies detail the late steps of the folding and maturation of the human mitoribosomal large subunit RNA that forms the catalytic core of the ribosome: the peptidyl transferase center (PTC).

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Fig. 1: Mitoribosomal maturation factors.
Fig. 2: Synthetic model of the late-stage large mitoribosomal subunit maturation process.

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Authors and Affiliations

  1. ARNA - UMR5320 CNRS - U1212 INSERM, Université de Bordeaux, IECB, Pessac, France

    Marie Sissler & Yaser Hashem

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  1. Marie Sissler
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  2. Yaser Hashem
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Correspondence to Marie Sissler or Yaser Hashem.

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The authors declare no competing interests.

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Sissler, M., Hashem, Y. Mitoribosome assembly comes into view. Nat Struct Mol Biol 28, 631–633 (2021). https://doi.org/10.1038/s41594-021-00640-3

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