Abstract
Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China.
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Acknowledgements
This study was supported by grants from the National Grand Program on Key Infectious Disease Control (2018ZX10302103-002, 2017ZX10202101-003), the Joint-Innovative Program in Healthcare for Special Scientific Research Projects of Guangzhou (201803040002), and Guangzhou Science and Technology Plan Project (202002030028).
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Handling Editor: Zhongjie Shi.
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The sequence was deposited in GenBank with the accession numbers MW693026 and MW693027.
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Lan, Y., Li, L., Cai, W. et al. Genetic characteristics of HIV-1 CRF06_cpx and CRF56_cpx strains isolated in Guangzhou, China. Arch Virol 166, 2853–2857 (2021). https://doi.org/10.1007/s00705-021-05198-5
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DOI: https://doi.org/10.1007/s00705-021-05198-5