Skip to main content

Advertisement

SpringerLink
Log in

Chitosan/polyvinyl alcohol/tannic acid multiple network composite hydrogel: preparation and characterization

  • Original Research
  • Published:
Iranian Polymer Journal Aims and scope Submit manuscript

Abstract

The development of easy and cost-effective strategies for making multifunctional hydrogels is of great scientific interest. Here, a chitosan/polyvinyl alcohol/tannic acid (CS/PVA/TA) composite hydrogel was prepared by a simple method of γ-ray-induced crosslinking and immersion in TA solution. The chemical composition, transparency, microstructure, mechanical properties and antibacterial activity of the obtained composite hydrogel were characterized by Fourier transform infrared spectroscopy (FTIR), ultraviolet–visible spectroscopy, scanning electron microscopy (SEM), tensile measurement, and antibacterial test, respectively. The immersion in TA not only provided a CS (Mw 20,000 g.mol−1)/PVA composite hydrogel with improved mechanical performance, i.e., tensile strength and elongation-at-break increased by 1100 and 487%, respectively, but also it preserved high transparency of the pure irradiated PVA hydrogel (transmittance exceeded 50% at 660 nm). In addition, the composite hydrogel possessed good antibacterial activity against gram-negative and gram-positive bacteria. The rationality of the immersion TA method in principle was proved by the hydrogen bond simulation. This work provides a simple method for the preparation of multifunctional hydrogels, suitable for large-scale production, and is expected to promote their application in the fields of biomedicine and wound dressings.

Graphic abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Glass S, Kühnert M, Abel B, Schulze A (2019) Controlled electron-beam synthesis of transparent hydrogels for drug delivery applications. Polymers 11:501

    Article  CAS  Google Scholar 

  2. Senol S, Akyol E (2018) Synthesis and characterization of hydrogels based on poly(2-hydroxyethyl methacrylate) for drug delivery under UV irradiation. J Mater Sci 53:14953–14963

    Article  CAS  Google Scholar 

  3. Kong WQ, Gao CD, Hu SF, Ren JL, Zhao LH, Sun RC (2017) Xylan-modified-based hydrogels with temperature/pH dual sensitivity and controllable drug delivery behavior. Materials 10:304

    Article  Google Scholar 

  4. Jiang S, Liu S, Feng W (2011) PVA hydrogel properties for biomedical application. J Mech Behav Biomed Mater 4:1228–1233

    Article  CAS  Google Scholar 

  5. Zhang C, Liang KL, Zhou D, Yang HJ, Liu X, Yin XZ, Xu WL, Zhou YS, Xiao P (2018) High-performance photopolymerized poly(vinyl alcohol)/silica nanocomposite hydrogels with enhanced cell adhesion. ACS Appl Mater Int 10:27692–27700

    Article  CAS  Google Scholar 

  6. Hong KH (2017) Polyvinyl alcohol/tannic acid hydrogel prepared by a freeze-thawing process for wound dressing applications. Polym Bull 74:2861–2872

    Article  CAS  Google Scholar 

  7. Mansur HS, Sadahira CM, Souza AN, Mansur AAP (2009) FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde. Mater Sci Eng C 28:539–548

    Article  Google Scholar 

  8. Nguyen TH, Ventura R, Min YK, Lee BT (2016) Genipin cross-linked polyvinyl alcohol-gelatin hydrogel for bone regeneration. J Biomed Sci Eng 9:419–429

    Article  CAS  Google Scholar 

  9. Wang HH, Shyr TW, Hu MS (1999) The elastic property of polyvinyl alcohol gel with boric acid as a crosslinking agent. J Appl Polym Sci 74:3046–3052

    Article  CAS  Google Scholar 

  10. Gough JE, Scotchford CA, Downes S (2002) Cytotoxicity of glutaraldehyde crosslinked collagen/poly(vinyl alcohol) films is by the mechanism of apoptosis. J Biomed Mater Res 61:121–130

    Article  CAS  Google Scholar 

  11. Peppas NA, Stauffer SR (1991) Reinforced uncrosslinked poly (vinyl alcohol) gels produced by cyclic freezing-thawing processes: a short review. J Control Release 16:305–310

    Article  CAS  Google Scholar 

  12. Mori Y, Tokura H, Yoshikawa M (1997) Properties of hydrogels synthesized by freezing and thawing aqueous polyvinyl alcohol solutions and their applications. J Mater Sci 32:491–496

    Article  CAS  Google Scholar 

  13. Bhowmick S, Mohanty S, Koul V (2016) Fabrication of transparent quaternized PVA/silver nanocomposite hydrogel and its evaluation as an antimicrobial patch for wound care systems. J Mater Sci Mater Med 27:160

    Article  Google Scholar 

  14. Rosiak JM, Ulański P (1999) Synthesis of hydrogels by irradiation of polymers in aqueous solution. Radiat Phys Chem 55:139–151

    Article  CAS  Google Scholar 

  15. Chen WX, Bao HY, Zhang MW (1985) Effect of gamma radiation on gelation in polyvinyl alcohol solutions. Radiat Phys Chem 26:43–47

    CAS  Google Scholar 

  16. Ajjia Z, Othmana I, Rosiakb JM (2002) Production of hydrogel wound dressings using gamma radiation. Nucl Instrum Meth B 229:375–380

    Article  Google Scholar 

  17. Salmawi KME (2007) Gamma radiation-induced crosslinked PVA/chitosan blends for wound dressing. J Macromol Sci A 44:541–545

    Article  Google Scholar 

  18. Jeong JO, Park JS, Kim YA, Yang SJ, Jeong SI, Lee JY, Lim YM (2020) Gamma ray-induced polymerization and cross-linking for optimization of PPy/PVP hydrogel as biomaterial. Polymers 12:111

    Article  CAS  Google Scholar 

  19. Ishak WHW, Ahmad I, Ramli S, Amin MCIM (2018) Gamma irradiation-assisted synthesis of cellulose nanocrystal-reinforced gelatin hydrogels. Nanomaterials 8:749

    Article  Google Scholar 

  20. Orlowski P, Krzyzowska M, Zdanowski R, Winnicka A, Nowakowska J, Stankiewicz W, Tomaszewska E, Celichowski G, Grobelny J (2013) Assessment of in vitro cellular responses of monocytes and keratinocytes to tannic acid modified silver nanoparticles. Toxicol In Vitro 27:1798–1808

    Article  CAS  Google Scholar 

  21. Kaczmarek B (2020) Tannic acid with antiviral and antibacterial activity as a promising component of biomaterials: a minireview. Materials 13:3224

    Article  CAS  Google Scholar 

  22. Shutava T, Prouty M, Kommireddy D, Lvov Y (2005) pH responsive decomposable layer-by-layer nanofilms and capsules on the basis of tannic acid. Macromolecules 38:2850–2858

    Article  CAS  Google Scholar 

  23. Erel-Unal I, Sukhishvili SA (2008) Hydrogen-bonded multilayers of a neutral polymer and a polyphenol. Macromolecules 41:3962–3970

    Article  CAS  Google Scholar 

  24. Ge WJ, Cao S, Shen F, Wang YY, Ren JL, Wang XH (2019) Rapid self-healing, stretchable, moldable, antioxidant and antibacterial tannic acid-cellulose nanofibril composite hydrogels. Carbohyd Polym 224:115147

    Article  CAS  Google Scholar 

  25. Chen YN, Jiao C, Zhao Y, Zhang J, Wang H (2018) Self-assembled polyvinyl alcohol-tannic acid hydrogels with diverse microstructures and good mechanical properties. ACS Omega 3:11788–11795

    Article  CAS  Google Scholar 

  26. Fan LH, Yang H, Yang J, Peng M, Hu J (2016) Preparation and characterization of chitosan/gelatin/PVA hydrogel for wound dressing. Carbohyd Polym 146:427–434

    Article  CAS  Google Scholar 

  27. Kadlubowski S, Grobelny J, Olejniczak W, Cichomski M, Ulanski P (2003) Pulses of fast electrons as a tool to synthesize poly(acrylic acid) nanogels: intramolecular cross-linking of linear polymer chains in additive-free aqueous solution. Macromolecules 36:2484–2492

    Article  CAS  Google Scholar 

  28. Varshney L (2007) Role of natural polysaccharides in radiation formation of PVA-hydrogel wound dressing. Nucl Instrum Meth B 255:343–349

    Article  CAS  Google Scholar 

  29. Fan HL, Wang L, Feng XD, Bu YZ, Wu DC, Jin ZX (2017) Supramolecular hydrogel formation based on tannic acid. Macromolecules 50:666–676

    Article  CAS  Google Scholar 

  30. Lawrie G, Keen I, Drew B, Chandler-Temple A, Rintoul L, Fredericks P (2007) Interactions between alginate and chitosan biopolymers characterized using FTIR and XPS. Biomacromol 8:2533–2541

    Article  CAS  Google Scholar 

  31. Li PP, Sirviö JA, Haapala A, Khakalo A, Liimatainen H (2019) Anti-oxidative and UV-absorbing biohybrid film of cellulose nanofibrils and tannin extract. Food Hydrocoll 92:208–217

    Article  CAS  Google Scholar 

  32. Ninan N, Forget A, Shastri VP, Voelcker NH, Blencowe A (2016) Antibacterial and anti-inflammatory pH-responsive tannic acid-carboxylated agarose composite hydrogels for wound healing. ACS Appl Mater Inter 8:28511–28521

    Article  CAS  Google Scholar 

  33. Zhang Y, Yang JC, Yu YX, Li YG (2005) Structural and hydrogen bond analysis for supercritical ethanol: a molecular simulation study. J Supercrit Fluids 36:145–153

    Article  CAS  Google Scholar 

  34. He Y, Zhu B, Inoue Y (2004) Hydrogen bonds in polymer blends. Prog Polym Sci 29:1021–1051

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Yun Wang for the help of the antibacterial measurement.

Funding

Leading Talents Fund in Science and Technology Innovation in Henan Province (194200510030); Scientific Research and Development Project of Henan Academy of Sciences (190704002); Outstanding Youth Talent Training Project of Henan Academy of Sciences (200404008); Fundamental scientific research fees of Henan Academy of Sciences (200604056).

Author information

Authors and Affiliations

  1. Henan Radiation New Materials Engineering Technology Research Center, Zhengzhou, 450015, Henan, China

    Wenhui Guo, Mingcheng Yang, Shubo Liu, Benshang Zhang & Yang Chen

  2. Institute of Isotope, Henan Academy of Sciences Co., Ltd, Zhengzhou, 450015, Henan, China

    Wenhui Guo, Mingcheng Yang, Shubo Liu, Benshang Zhang & Yang Chen

  3. Energy Research Institute, Henan Academy of Sciences Co., Ltd, Zhengzhou, 450015, Henan, China

    Xiuqiang Zhang

Authors
  1. Wenhui Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mingcheng Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shubo Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiuqiang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Benshang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yang Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization, WG and MY; methodology, MY, WG, SL, XZ, and YC; writing—original draft preparation, WG, MY, XZ, and BZ; writing—review and editing WG, MY, and BZ; Project administration, MY. We confirmed that the order of authors listed in the manuscript has been approved by all named authors. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Mingcheng Yang.

Ethics declarations

Conflict of interest

There are no conflicts to declare.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guo, W., Yang, M., Liu, S. et al. Chitosan/polyvinyl alcohol/tannic acid multiple network composite hydrogel: preparation and characterization. Iran Polym J 30, 1159–1168 (2021). https://doi.org/10.1007/s13726-021-00966-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13726-021-00966-1

Keywords

Search

Navigation