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Ultrasonic cavitation bubble- and gas bubble-assisted adsorption of paclitaxel from Taxus chinensis onto Sylopute

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Abstract

This study presents a technique for adsorption of paclitaxel on Sylopute using ultrasonic cavitation bubbles and gas bubbles. Compared with the conventional adsorption (control), the adsorbed amount and adsorption rate constant increased, respectively, by 1.27–1.44 times and 7.44–9.71 times in ultrasonic adsorption (with mixing at 80–250 W), 1.14–1.27 times and 4.63–9.31 times in ultrasonic adsorption (without mixing at 80–250 W), and 1.06–1.19 times and 1.18–1.34 times in gas bubble-adsorption (without mixing at 1.15–9.41 L/min). As a result of investigating the adsorption mechanism in which cavitation bubbles were introduced, it was shown that microjets and shock waves produced by bubble collapse, rather than the bubble itself, drastically improve mass transport in the pores of the adsorbent, thereby completely eliminating intraparticle diffusion resistance. In the case of gas bubbles, although the intraparticle diffusion coefficient increased by 1.34–1.75 times compared with the control, there was a limitation in promoting intraparticle diffusion.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Grant Number: 2021R1A2C1003186).

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Authors and Affiliations

  1. Department of Chemical Engineering, Kongju National University, Cheonan, 31080, Korea

    Da-Yeon Kang & Jin-Hyun Kim

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  1. Da-Yeon Kang
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  2. Jin-Hyun Kim
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Correspondence to Jin-Hyun Kim.

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Kang, DY., Kim, JH. Ultrasonic cavitation bubble- and gas bubble-assisted adsorption of paclitaxel from Taxus chinensis onto Sylopute. Korean J. Chem. Eng. 38, 2286–2293 (2021). https://doi.org/10.1007/s11814-021-0852-y

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  • DOI: https://doi.org/10.1007/s11814-021-0852-y

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