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Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques and tangles that have become the fifth leading cause of death worldwide. Previous studies have found that thioredoxin interacting protein (TXNIP) expression was increased during the development of AD neurons. TXNIP separates from the TXNIP-thioredoxin complex, and the TXNIP-NLRP3 complex assembles ASC and pro-caspase-1 to form the NLRP3 inflammasome, which triggers AD inflammation and apoptosis. CB-dock was used to explore whether 21 natural flavonoids and phenols target TXNIP based on references. Docking results showed that rutin, puerarin, baicalin, luteolin and quercetin are the most potent TXNIP inhibitors, and among them, rutin as the most effective flavonoid. And rosmarinic acid is the most potent TXNIP inhibitor of phenols. These phytochemicals could be helpful to find the lead compounds in designing and developing novel agents for Alzheimer’s disease.

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Acknowledgements

This study were supported by the National Natural Science Foundation of China (82004180, 81873351); the Distinguished Young Scholars Project of Natural Science Foundation of Anhui Province in China (1908085J27); the Key Project of Overseas Visits for the Excellent Young Talents in Universities of Anhui Province in China (gxgwfx2020041); the Project Foundation of Support Program for the Excellent Young Faculties in Universities of Anhui Province in China (gxyq2019033).

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  1. Meng Zhang and Guanhua Hu contributed equally to this work.

Authors and Affiliations

  1. Department of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China

    Meng Zhang, Guanhua Hu, Nan Shao, Yunpeng Qin, Qian Chen, Yan Wang, Peng Zhou & Biao Cai

  2. Research Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, Anhui, 230012, China

    Peng Zhou & Biao Cai

  3. Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, 230012, China

    Peng Zhou & Biao Cai

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  1. Meng Zhang
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Zhang, M., Hu, G., Shao, N. et al. Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols. Inflammopharmacol 29, 1317–1329 (2021). https://doi.org/10.1007/s10787-021-00861-4

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