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Association of triglyceride–glucose index with intra- and extra-cranial arterial stenosis: a combined cross-sectional and longitudinal analysis

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Abstract

Purpose

This study aimed to assess the cross-sectional and longitudinal associations of the triglyceride glucose (TyG) index, a simple surrogate marker of insulin resistance, with intra-cranial and extra-cranial artery stenosis (ICAS and ECAS) in Chinese adults.

Methods

Participants were recruited from the Asymptomatic Polyvascular Abnormalities Community study, 5381 participants were enrolled in the cross-sectional analysis, then 3447 and 1853 participants in the longitudinal analysis for incident ICAS and ECAS, respectively. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multivariable logistic analysis was used to calculate odds ratio (OR) and 95% confidence interval (CI).

Results

The results of the cross-sectional and longitudinal analysis were basically the same, as the fully adjusted OR comparing participants in the highest tertile versus lowest tertile of the TyG index was 1.34 (95% CI, 1.13–1.59) for the prevalence of ECAS and 1.85 (95% CI, 1.26–2.71) for incident ECAS, respectively. The addition of TyG index to a conventional model had an incremental effect on the predictive value for ECAS. However, we did not observe any significant association between the TyG index and ICAS.

Conclusions

Elevated TyG index was significantly associated with a higher risk of ECAS, but not with ICAS in Chinese adults. This conclusion lends support to the clinical significance of the TyG index for the assessment of artery stenosis, especially for ECAS.

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Data availability

Data are available to researchers on request for purposes of reproducing the results or replicating the procedure by directly contacting the corresponding author.

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Acknowledgements

We thank all the participants of the APAC study for their invaluable contributions.

Funding

This work was supported by the National Key Research and Development Program of China (2018YFC1312400 and 2018YFC1312402), Beijing Municipal Administration of Hospitals Incubating Program (PX2020021), Young Elite Scientists Sponsorship Program by CAST (2018QNRC001), Beijing Excellent Talents Training Program (2018000021469G234), Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2019-I2M-5-029), Beijing Municipal Committee of Science and Technology (Z201100005620010), and Beijing Natural Science Foundation (Z200016).

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Author notes

  1. These authors contributed equally: Anxin Wang, Xue Tian

Authors and Affiliations

  1. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Anxin Wang, Xiaoli Zhang, Jiahuan Guo & Xingquan Zhao

  2. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Anxin Wang, Xiaoli Zhang, Jiahuan Guo & Xingquan Zhao

  3. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China

    Xue Tian & Yingting Zuo

  4. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China

    Xue Tian & Yingting Zuo

  5. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China

    Shuohua Chen & Shouling Wu

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  1. Anxin Wang
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Contributions

A.W. and X.T. made substantial contributions to study design, data collection, data analysis, and manuscript writing. S.W. and X.Z. (Xingquan Zhao) made substantial contributions to study design and intellectual direction. Y.Z., S.C., X.Z. (Xiaoli Zhang), and J.G. made contributions to data collection. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Shouling Wu or Xingquan Zhao.

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The authors declare no competing interests.

Ethics approval and consent to participate

The study was performed according to the guidelines of the Helsinki Declaration and was approved by the Ethics Committee of Kailuan General Hospital (approval number: 2006-05) and Beijing Tiantan Hospital (approval number: 2010-014-01). All participants were agreed to take part in the study and provided informed written consent.

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Wang, A., Tian, X., Zuo, Y. et al. Association of triglyceride–glucose index with intra- and extra-cranial arterial stenosis: a combined cross-sectional and longitudinal analysis. Endocrine 74, 308–317 (2021). https://doi.org/10.1007/s12020-021-02794-y

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  • DOI: https://doi.org/10.1007/s12020-021-02794-y

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