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Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides

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Abstract

Organophosphorus (OP) compounds are typically a broad class of compounds that possess various uses such as insecticides, pesticides, etc. One of the most evil utilizations of these compounds is as chemical warfare agents, which pose a greater threat than biological weapons because of their ease of access. OP compounds are highly toxic compounds that cause irreversible inhibition of enzyme acetylcholinesterase, which is essential for hydrolysis of neurotransmitter acetylcholine, leading to series of neurological disorders and even death. Due to the extensive use of these organophosphorus compounds in agriculture, there is an increase in the environmental burden of these toxic chemicals, with severe environmental consequences. Hence, the rapid and sensitive, selective, real-time detection of OP compounds is very much required in terms of environmental protection, health, and survival. Several techniques have been developed over a few decades to easily detect them, but still, numerous challenges and problems remain to be solved. Major advancement has been observed in the development of sensors using the spectroscopic technique over recent years because of the advantages offered over other techniques, which we focus on in the presented review.

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Acknowledgements

Muskan and Ashima are thankful to the Department of Pharmaceutical, Ministry of Chemicals and fertilizers for providing fellowship. NIPER-R/Communication/124.

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  1. Muskan Gori, Ashima Thakur have contributed equally.

Authors and Affiliations

  1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India

    Muskan Gori, Ashima Thakur & Abha Sharma

  2. Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, India

    S. J. S. Flora

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Gori, M., Thakur, A., Sharma, A. et al. Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides. Top Curr Chem (Z) 379, 33 (2021). https://doi.org/10.1007/s41061-021-00345-7

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