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Magnetic Ganoderma Lucidum Spores (mGLS): A Novel Regulatable Targeted Drug Delivery System

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Abstract

In the past decades, many materials have been studied as carriers for targeted drug delivery. However, there is a need for utilizable and selective carrier materials with few side effects. Here, the magnetic Ganoderma Lucidum Spores (mGLS) as a highly efficient targeted drug delivery carrier were explored. Then the regulatable targeted drug delivery system was verified by loading and releasing of the 5-Fluorouracil (5-FU). The results showed that the maximum of the loaded 5-FU reached 250.23 mg·g−1 in the mGLS. The cumulative release of the 5-FU for the drug delivery system could reach 80.11% and 67.14% in the PBS and HCl after 48 h, respectively. In addition, this system showed the good pharmacokinetic properties in vivo. After 12 h, the blood concentration in the 5-FU@mGLS group kept at 5.3 µg·mL−1 and was four times higher than that in the 5-FU group. In summary, the GLS as a natural microscale core-shell structures appears the striking application in carrier material for oral drug delivery.

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Acknowledgment

This work was supported by National Key R&D Program of China (No. 2018YFB1105400), Jilin Provincial Science and Technology Program (Nos. 20190702002GH, 2020C022-1, and YDZJ202102CXJD 007), and Programme of Introducing Talents of Discipline to Universities (D17017).

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Authors and Affiliations

  1. Changchun University of Science and Technology, Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun, 130022, China

    Bin Han, Zhankun Weng, Xin Zhao, Qinhan Zhang, Kaige Qu & Zuobin Wang

  2. International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun, 130022, China

    Bin Han, Zhankun Weng, Xin Zhao, Qinhan Zhang, Kaige Qu & Zuobin Wang

  3. School of Life Sciences, Changchun University of Science and Technology, Changchun, 130022, China

    Bin Han, Yuhan Wu & Jingmei Li

  4. Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China

    Bojian Liang

  5. School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, China

    Fenguo Zhou & Guixia Liu

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  1. Bin Han
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  2. Zhankun Weng
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  4. Xin Zhao
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Correspondence to Zhankun Weng or Jingmei Li.

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Han, B., Weng, Z., Wu, Y. et al. Magnetic Ganoderma Lucidum Spores (mGLS): A Novel Regulatable Targeted Drug Delivery System. J Bionic Eng 18, 915–926 (2021). https://doi.org/10.1007/s42235-021-0059-2

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