Abstract
This report focused on a novel nano-drug delivery system (GA-DTX-PVP/CuS-TSL) by combining glycyrrhetinic acid, copper sulfide nanoparticles, and docetaxel (DTX) with thermo-sensitive liposomes, which not only could achieve drug targeting distribution, but also could combine chemotherapy with phototherapy for tumor therapy. The particle size and DL of GA-DTX-PVP/CuS-TSL were 251.2 ± 0.40 nm (PDI = 0.15) and 7.51 ± 0.15%, respectively. The physicochemical properties, pharmacokinetics, biodistribution, and antitumor effects in vitro and in vivo of GA-DTX-PVP/CuS-TSL were also carried out. The result showed GA-DTX-PVP/CuS-TSL had obvious slower and temperature-dependent drug release effect when compared with DTX solution and DTX-PVP/CuS-TSL. In comparison to DTX solution group, the cell growth inhibition rates of DTX-PVP/CuS-TSL and GA-DTX-PVP/CuS-TSL groups on SMMC-7721 cells were significantly enhanced under the same conditions. Furthermore, when combined with 808 nm laser irradiation, the cell growth inhibition rates of DTX-PVP/CuS-TSL and GA-DTX-PVP/CuS-TSL groups were further enhanced. Moreover, GA-DTX-PVP /CuS-TSL could prolong the circulation time of DTX in vivo and improve the targeted distribution of DTX at the tumor sites of S180 tumor-bearing mice. When combined with 808 nm of near-infrared light irradiation, GA-DTX-PVP/CuS-TSL had much more obvious anti-tumor activity both in vitro and in vivo than that of DTX solution and DTX-PVP/CuS-TSL. This study may provide certain theoretical basis for safe and effective treatment of tumor.
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References
Deng X, Li K, Cai X et al (2017) A hollow-structured CuS@Cu2S@Au nanohybrid: synergistically enhanced photothermal efficiency and photoswitchable targeting effect for cancer theranostics. Adv Mater 29(36):1701266. https://doi.org/10.1002/adma.201701266
Dibaba ST, Caputo R, Ws Xi et al (2019) NIR Light-degradable antimony nanoparticle-based drug-delivery nanosystem for synergistic chemo-photothermal therapy in vitro. ACS Appl Mater Inter 11:48290–48299. https://doi.org/10.1021/acsami.9b20249
Emami J, Kazemi M, Hasanzadeh F et al (2020) Novel pH-triggered biocompatible polymeric micelles based on heparin-α-tocopherol conjugate for intracellular delivery of docetaxel in breast cancer. Pharm Dev Technol 25:1–45. https://doi.org/10.1080/10837450.2019.1711395
Fumi Y, Tsukuru A, Yajuan Z et al (2019) Preferential tumor accumulation of polyglycerol functionalized nanodiamond conjugated with cyanine dye leading to near-infrared fluorescence in vivo tumor imaging. Small 15:1901930–1901937. https://doi.org/10.1002/smll.201901930
Han X, Zhang J, Shi D et al (2019) Targeting thioredoxin reductase by ibrutinib promotes apoptosis of SMMC-7721 cells. Indian J Pharmacol 369:212–222. https://doi.org/10.1124/jpet.118.254862
Huang Y, Br Gu, Liu C et al (2019) Thermosensitive liposome-mediated drug delivery in chemotherapy: mathematical modelling for spatio-temporal drug distribution and model -based optimisation. Pharmaceutics 11:1–14. https://doi.org/10.3390/pharmaceutics11120637
Jaber E, Moloud K, Farshid H et al (2020) Novel pH-triggered biocompatible polymeric micelles based on heparin–α-tocopherol conjugate for intracellular delivery of docetaxel in breast cancer. Pharm Dev Technol 25:1–45. https://doi.org/10.1080/10837450.2019.1711395
Lan Z, Gong B (2020) Uncertainty analysis of key factors affecting fracture height based on Box-Behnken method. Elsevier Ltd 228:1–23. https://doi.org/10.1016/j.engfracmech.2020.106902
Lee S, Jung JS, Jo G et al (2019) Near-infrared fluorescent sorbitol probe for targeted photothermal cancer therapy. Cancers 11:1–10. https://doi.org/10.3390/cancers11091286
Li J, Xu H, Ke X (2012) The anti-tumor performance of docetaxel liposomes surface-modified with glycyrrhetinic acid. J Drug Target 20:467–473. https://doi.org/10.3109/1061186x.2012.685475
Lin K, Cao YB, Zheng D et al (2020) Facile phase transfer of hydrophobic Fe3O4@Cu2-xS nanoparticles by red blood cell membrane for MRI and phototherapy in the second near-infrared window. J Mater Chem B 8:1202–1211. https://doi.org/10.1039/C9TB02766A
Li M, Wang Y, Jiang S et al (2020) Biodistribution and biocompatibility of glycyrrhetinic acid and galactose-modified chitosan nanoparticles as a novel targeting vehicle for hepatocellular carcinoma. Nanomedicine-UK 15:145–161. https://doi.org/10.2217/nnm-2018-0455
Liu F, Lin S, Zhang C et al (2019a) The novel nature microtubule inhibitor Ivalin induces G2/M arrest and apoptosis in human hepatocellular carcinoma SMMC-7721 cells in vitro. Medicina 55:1–6. https://doi.org/10.3390/medicina55080470
Liu Y, Ji M, Wang P (2019b) Recent advances in small copper sulfide nanoparticles for molecular imaging and tumor therapy. Mol Pharm 16(8):3322–3332. https://doi.org/10.1021/acs.molpharmaceut.9b00273
Marjan AA, Roya B, Jafar M et al (2019) Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release. J Control Release 315:1–22. https://doi.org/10.1016/j.jconrel.2019.09.018
Mcp A, Rvg B, Mamr A et al (2020) Structural properties of sulfur copper (CuS) nanocrystals grown by chemical bath deposition. Optik 208:164518. https://doi.org/10.1016/j.ijleo.2020.164518
Mohamed D, Mohammed AS (2020) Monoolein cubic nanoparticles as novel carriers for docetaxel. J Drug Deliv Sci Tec 56:1–36. https://doi.org/10.1016/j.jddst.2020.101501
Negishi M, Irie A, Nagata N et al (1991) Specific binding of glycyrrhetinic acid to the rat liver membrane. BBA-Biomembranes 1066:77–82. https://doi.org/10.1016/0005-2736(91)90253-5
Nekouei, (2020) Application of synthesized nano-CuS photocatalyst for degradation of ofloxacin and its by-products. Sep Sci and Technol 55:1–13. https://doi.org/10.1080/01496395.2019.1577893
Poudela K, Gautama M, Jinb S et al (2019) Copper sulfide: an emerging adaptable nanoplatform in cancer theranostics. Int J Pharm 562:135–150. https://doi.org/10.1016/j.ijpharm.2019.03.043
Satomi Y, Nishino H, Shibata S (2005) Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. Anticancer Res 25:4043–4047. https://doi.org/10.1039/b719498f
Shamraiz U, Hussain R, Badshah A (2016) Fabrication and applications of copper sulphide (CuS) nanostructures. J Solid State Chem 238:25–40. https://doi.org/10.1016/j.jssc.2016.02.046
Song J, Zhang N, Zhang L et al (2019) IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer. Int J Nanomed 14:2757–2772. https://doi.org/10.2147/IJN.S203108
Tang L, Chen R, Xu X (2020) Synthetic lethality: a promising therapeutic strategy for hepatocellular carcinoma. Cancer Lett 476:120–128. https://doi.org/10.1016/j.canlet.2020.02.016
Tian Q, Jiang F, Zou R et al (2011) Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7 % heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 5:9761–9771. https://doi.org/10.1021/nn203293t
van Rhoon GC, Franckena M, ten Hagen TL (2020) A moderate thermal dose is sufficient for effective free and TSL based thermochemotherapy. Adv Drug Deliver Rev 4:1–12. https://doi.org/10.1016/j.addr.2020.03.006
Wang CM, Wang XY, Chen Y et al (2020a) In-vitro photothermal therapy using plant extract polyphenols functionalized graphene sheets for treatment of lung cancer. J Photoch Photobio B 204:1–30. https://doi.org/10.1016/j.jphotobiol.2019.111587
Wang YZ, Lei B, Sun MJ et al (2020b) Accurate targeting and controllable release of hybrid liposome containing a stretchable copolymer. Macromol Chem Phys 221:1–9. https://doi.org/10.1002/macp.201900536
Wang Z, Yu N, Li X et al (2020c) Galvanic exchange-induced growth of Au nanocrystals on CuS nanoplates for imaging guided photothermal ablation of tumors. Chem Eng J 381:1–11. https://doi.org/10.1016/j.cej.2019.122613
Xu W, Zhu S, Liang Y et al (2015) Nanoporous CuS with excellent photocatalytic property. Sci Rep 5:18125. https://doi.org/10.1038/srep18125
Yang Z, Li H, Feng SH (2018) Multiform sulfur adsorption centers and copper-terminated active sites of nano-CuS for efficient elemental mercury capture from coal combustion flue gas. ACS J Surfaced Colloid 34:8739–8749. https://doi.org/10.1021/acs.langmuir.8b01181
Zhao Q, Wang X, Yang M et al (2019) Multi-stimuli responsive mesoporous carbon nano-platform gated by human serum albumin for cancer thermo-chemotherapy. Colloids Surfaces b- Biointerfaces 184:110532. https://doi.org/10.1016/j.colsurfb.2019.110532
Zhu X, Zhang Y, Huang H et al (2017) Folic acid-modified and functionalized CuS nanocrystal- based nanoparticles for combined tumor Chemo- and Photothermal Therap. J Drug Target 25:425–435. https://doi.org/10.1080/1061186X.2016.1266651
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The authors are grateful for the financial support of the National Nature Science Foundation of China [No. 81803740].
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This work was supported by grant from the National Nature Science Foundation of China [No. 81803740].
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Zhu, X., Huang, S., Li, L. et al. Glycyrrhetinic acid-decorated and docetaxel-loaded thermosensitive liposomes for combination therapy against hepatocellular carcinoma . J Nanopart Res 23, 158 (2021). https://doi.org/10.1007/s11051-021-05273-7
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DOI: https://doi.org/10.1007/s11051-021-05273-7