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Sesquicillin F, a new insecticidal meroterpenoid produced by Mariannaea macrochlamydospora FKI-4735

Abstract

A new insecticidal meroterpenoid, named sesquicillin F (1), has been isolated from a culture broth of Mariannaea macrochlamydospora FKI-4735, together with 4-hydroxy-5,6-dimethylpyran-2-one (2). Compounds 1 and 2 were insecticidally active against Halyomorpha halys at 1 ppm.

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Acknowledgements

We are grateful to Distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support and valuable guidance and suggestions. We are grateful to Dr Kenichiro Nagai (School of Pharmacy, Kitasato University) for measurement of MS, and Dr Akari Ikeda (Ōmura Satoshi Memorial Institute, Kitasato University) for useful discussion. We strongly thank Mr Koshi Gunjima, Mr Shigehito Takeda, Dr Yoshiaki Kato, Mrs Haruka Takeda, Mr Hideki Yamashita and Mr Fumihiko Ikejiri (BASF Japan Ltd.) for providing the H. halys organisms and constructive suggestions. This study was partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from the Japan Agency for Medical Research & Development (AMED) under Grant Number JP20am0101096.

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KS-Study design, Laboratory works (fermentation, isolation, structure elucidation, derivative preparation and biological evaluation), data analysis and manuscript writing; TK-Laboratory works (fermentation, isolation, structure elucidation); MI, YA and TS-Study design, data analysis and manuscript correction; AK-Derivative preparation supports and manuscript correction; RM and KN-Isolation and taxonomy of the producing fungus and manuscript correction.

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Correspondence to Masato Iwatsuki.

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Sakai, K., Iwatsuki, M., Kaneta, T. et al. Sesquicillin F, a new insecticidal meroterpenoid produced by Mariannaea macrochlamydospora FKI-4735. J Antibiot 74, 817–820 (2021). https://doi.org/10.1038/s41429-021-00456-9

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