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PHASE SEPARATION

Insulating proteins drop by drop

Nature Chemical Biology volume 17, pages 934–936 (2021)Cite this article

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Liquid–liquid phase separation, yielding membraneless organelles, allows for the sequestration and functional insulation of cellular proteins. A modularly built, synthetic membraneless organelle platform enables efficient control over endogenous cellular activities by knockdown of protein function or controlled protein release.

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Fig. 1: LLPS-based insulation of endogenous enzymes.

References

  1. Alberti, S., Gladfelter, A. & Mittag, T. Cell 176, 419–434 (2019).

    Article  CAS  Google Scholar 

  2. Bracha, D., Walls, M. T. & Brangwynne, C. P. Nat. Biotechnol. 37, 1435–1445 (2019).

    Article  CAS  Google Scholar 

  3. Ölçücü, G., Klaus, O., Jaeger, K.E., Drepper, T. & Krauss, U. ACS Sustain. Chem. Eng. https://doi.org/10.1021/acssuschemeng.1c02045 (2021).

  4. Garabedian, M. V. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00840-4 (2021).

  5. Haruki, H., Nishikawa, J. & Laemmli, U. K. Mol. Cell 31, 925–932 (2008).

    Article  CAS  Google Scholar 

  6. Schuster, B. S. et al. Nat. Commun. 9, 2985 (2018).

    Article  Google Scholar 

  7. Zhang, W. et al. Nat. Methods 14, 391–394 (2017).

    Article  Google Scholar 

  8. Peeples, W. & Rosen, M. K. Nat. Chem. Biol. 17, 693–702 (2021).

    Article  CAS  Google Scholar 

  9. Zhao, E. M. et al. Nat. Chem. Biol. 15, 589–597 (2019).

    Article  CAS  Google Scholar 

  10. Wei, S. P. et al. Nat. Chem. Biol. 16, 1143–1148 (2020).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Molecular Enzyme Technology, Heinrich Heine University Düsseldorf, Institute of Bio- and Geosciences (IBG-1) Biotechnology, Forschungszentrum Jülich, Jülich, Germany

    Ulrich Krauss

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  1. Ulrich Krauss
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Correspondence to Ulrich Krauss.

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The author declares no competing interests.

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Krauss, U. Insulating proteins drop by drop. Nat Chem Biol 17, 934–936 (2021). https://doi.org/10.1038/s41589-021-00846-y

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