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Quinofuracins F – I, new quinofuracin derivatives produced by Staphylotrichum boninense PF1444

The Journal of Antibiotics volume 74, pages 758–762 (2021)Cite this article

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Abstract

Four new quinofuracins F – I were isolated from the culture broth of Staphylotrichum boninense PF1444. The structures of quinofuracins F – I were elucidated by extensive spectroscopic analysis. These quinofuracins induced tumor suppressor protein p53-dependent cell death in human glioblastoma LNZTA3 cells.

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Acknowledgements

We are grateful to Ms Y Kubota and Dr K Iijima (BIKAKEN) for the measurements of NMR and MS spectroscopic data; Mr K Sumiyoshi, Ms N Sumida, and Ms K Kobayashi (Meiji Seika Pharma) for fermentation of quinofuracins; and Ms I Ohsawa and Ms T Miyazawa (BIKAKEN) for technical assistance. This work was supported by JSPS KAKENHI Grant Number JP19K07311.

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Authors and Affiliations

  1. Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Japan

    Daisuke Tatsuda, Masahide Amemiya, Ryuichi Sawa & Manabu Kawada

  2. Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan

    Isao Momose

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  1. Daisuke Tatsuda
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  2. Masahide Amemiya
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  3. Ryuichi Sawa
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  4. Isao Momose
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  5. Manabu Kawada
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Correspondence to Isao Momose.

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Tatsuda, D., Amemiya, M., Sawa, R. et al. Quinofuracins F – I, new quinofuracin derivatives produced by Staphylotrichum boninense PF1444. J Antibiot 74, 758–762 (2021). https://doi.org/10.1038/s41429-021-00452-z

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