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Assessment of a Possibility to Differentiate the Tumor Histological Type and Localization in Patients with Lung Cancer by the Composition of Exhaled Air

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Abstract

In clinical practice, exhaled air analysis is a promising approach for diagnosing lung cancer due to a possibility of rapid and noninvasive sampling. We analyzed the exhaled air of 80 patients with lung cancer to identify differences in the profiles of volatile organic compounds in patients with different histological types and localization of cancer using gas chromatography–mass spectrometry. Some volatile organic compounds and their ratios have been identified, statistically signficant differences in concentrations of which have been found in samples with different localization and histological type.

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ACKNOWLEDGMENTS

The work was performed using scientific equipment from the Center for Collective Use “Ecological Analytical Center” of the Kuban State University, unique identifier RFMEFI59317X0008.

Funding

The research was supported by the RF Ministry of Science and Higher Education (project no. FZEN-2020-0022) and the Russian Foundation for Basic Research (project no. 20-33-90033).

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Authors and Affiliations

  1. Kuban State University, 350040, Krasnodar, Russia

    E. M. Gashimova, A. Z. Temerdashev, A. K. Osipova & E. V. Dmitrieva

  2. Research Institute—Ochapovsky Regional Clinical Hospital no. 1, 350086, Krasnodar, Russia

    V. A. Porkhanov, I. S. Polyakov & D. V. Perunov

Authors
  1. E. M. Gashimova
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  2. A. Z. Temerdashev
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  6. A. K. Osipova
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Correspondence to E. M. Gashimova.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in the studies involving human participants were in accordance with the standards of the Ethics Committee of the Research Institute—Ochapovsky Regional Clinical Hospital of the Ministry of Health of the Krasnodar krai (protocol no. 122 of the Meeting of the Committee on December 19, 2019). Informed consent was obtained from all individual participants involved in the study.

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Translated by O. Zhukova

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Gashimova, E.M., Temerdashev, A.Z., Porkhanov, V.A. et al. Assessment of a Possibility to Differentiate the Tumor Histological Type and Localization in Patients with Lung Cancer by the Composition of Exhaled Air. J Anal Chem 76, 975–980 (2021). https://doi.org/10.1134/S1061934821080050

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  • DOI: https://doi.org/10.1134/S1061934821080050

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