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Green Emission Carbon Nanodots as Fluorescence Turn-on Probe for Detecting Picolinic Acid

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Abstract

A new strategy for the determination of picolinic acid (PLA) is developed by utilizing green-emissive boron and nitrogen co-doped carbon nanodots (BNCNDs) and Cu2+ ion. Hydroquinone, uric acid and boric acid act as carbon, nitrogen and boron sources for BNCNDs synthesis, respectively. Interestingly, the green emission of BNCNDs is quenched in the presence of Cu2+ by electron transfer. Upon addition of the specific reagent (PLA), Cu2+ ion is removed from the surface of BNCNDs owing to the formation of a strong complex between PLA and Cu2+ ion, which leads to a significant fluorescence recovery of BNCNDs. The “turn-on” phenomenon allows to determine PLA by a very simple method. This chemosensing method displays a linear range from 50 nM to 80 μM with a detection limit of 14 nM (3σ/k) for PLA. The method was applied to the determination of PLA in fetal bovine serum samples with the recoveries between 94 and 106%, which shows that this method has potential for use in applications to real samples.

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Funding

We greatly appreciate the support of the National Natural Science Foundation of China (21705140, 21876144) and the Natural Science Foundation of Jiangsu Province (BK20170474) and the work was supported by Joint Open Fund of Jiangsu Collaborative Innovation Center for Ecological Building Material and Environmental Protection Equipments and Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province.

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    Authors and Affiliations

    1. College of Biochemical Engineering, Anhui Polytechnic University, 241000, Wuhu, Anhui, P.R. China

      Yu-Jie Ding & Xing Jin

    2. School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, 224051, Yancheng, P.R. China

      Xing Jin, Zhong-Xia Wang & Wei Wang

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    1. Yu-Jie Ding
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    2. Xing Jin
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    Correspondence to Zhong-Xia Wang or Wei Wang.

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    There are no conflicts to declare. Yu-Jie Ding and Xing Jin contributed equally to this work.

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    Ding, YJ., Jin, X., Wang, ZX. et al. Green Emission Carbon Nanodots as Fluorescence Turn-on Probe for Detecting Picolinic Acid. J Anal Chem 76, 920–929 (2021). https://doi.org/10.1134/S1061934821080037

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