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Impact of brain-derived neurotrophic factor Val66Met polymorphism and response to escitalopram or paroxetine in obsessive–compulsive disorder

Published online by Cambridge University Press:  27 July 2021

Ghina Harika-Germaneau Open the ORCID record for Ghina Harika-Germaneau [Opens in a new window] ,
Nicolas Langbour ,
Sylvie Patri ,
Marcello Solinas ,
Armand Chatard ,
Bruno Millet ,
Farshad Hashemian ,
Marie-Christine Pérault-Pochat ,
Nematollah Jaafari  and
Claire Lafay-Chebassier Open the ORCID record for Claire Lafay-Chebassier [Opens in a new window]
Ghina Harika-Germaneau
Affiliation:
Unité de Recherche Clinique Intersectorielle en Psychiatrie, Centre Hospitalier Henri Laborit, Poitiers, France INSERM U1084 - Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, Poitiers, France
Nicolas Langbour
Affiliation:
Unité de Recherche Clinique Intersectorielle en Psychiatrie, Centre Hospitalier Henri Laborit, Poitiers, France
Sylvie Patri
Affiliation:
Département de Génétique, CHU de Poitiers, Poitiers, France
Marcello Solinas
Affiliation:
Unité de Recherche Clinique Intersectorielle en Psychiatrie, Centre Hospitalier Henri Laborit, Poitiers, France INSERM U1084 - Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, Poitiers, France
Armand Chatard
Affiliation:
Unité de Recherche Clinique Intersectorielle en Psychiatrie, Centre Hospitalier Henri Laborit, Poitiers, France Département de Psychologie - CNRS 7295, Université de Poitiers, Poitiers, France
Bruno Millet
Affiliation:
AP-HP, Service de Psychiatrie Adulte de la Pitié-Salpêtrière, Institut du Cerveau, ICM, Sorbonne Université, Paris, France
Farshad Hashemian
Affiliation:
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Marie-Christine Pérault-Pochat
Affiliation:
INSERM U1084 - Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, Poitiers, France Service de Pharmacologie Clinique et Vigilances, CHU de Poitiers, Poitiers, France Centre d’Investigation Clinique - INSERM CIC 1402, CHU de Poitiers, Poitiers, France
Nematollah Jaafari
Affiliation:
Unité de Recherche Clinique Intersectorielle en Psychiatrie, Centre Hospitalier Henri Laborit, Poitiers, France INSERM U1084 - Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, Poitiers, France
Claire Lafay-Chebassier*
Affiliation:
INSERM U1084 - Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, Poitiers, France Service de Pharmacologie Clinique et Vigilances, CHU de Poitiers, Poitiers, France Centre d’Investigation Clinique - INSERM CIC 1402, CHU de Poitiers, Poitiers, France
*
*Author for correspondence: Claire Lafay-Chebassier, Email: claire.lafay@univ-poitiers.fr
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Abstract

Objective

Obsessive–compulsive disorder (OCD) is a severe psychiatric disorder characterized by its heterogeneous nature and by different dimensions of obsessive–compulsive (OC) symptoms. Serotonin reuptake inhibitors (SRIs) are used to treat OCD, but up to 40% to 60% of patients do not show a significant improvement with these medications. In this study, we aimed to test the impact of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the efficacy of antidepressants in OCD overall, and in relation to the different OC dimensions.

Methods

In a 6-month prospective treatment study, 69 Caucasian OCD patients were treated with escitalopram for 24 weeks or with escitalopram for 12 weeks followed by paroxetine for an additional 12-week period. Patients were genotyped and assessed for treatment response. The main clinical outcomes were improvement of the Yale-Brown Obsessive–Compulsive Scale score and in different OC symptom dimension scores.

Results

The Val/Val group comprised 43 (62%) patients, the Val/Met and Met/Met group comprised 26 (38%) patients. Forty-two patients were classified as responders at 12 weeks and 38 at 24 weeks; no significant association was found between BDNF Val66Met and SRIs response at 12 and 24 weeks. In analyses of the different OC symptom dimensions, the Met allele was associated with a slightly reduced score in the aggressive/checking dimension at 6 months (P = .048).

Conclusions

Our findings do not support the usefulness of BDNF Val66Met genotyping to predict overall response to treatment with SRIs in OCD; they did however suggest a better outcome at 6 months for the aggressive/checking symptom dimension for patients carrying the Met allele.

Keywords

BDNF Val66Met polymorphismobsessive–compulsive disorderOC symptom dimensionsantidepressantsresponse
Type
Original Research
Information
CNS Spectrums , Volume 27 , Issue 5 , October 2022 , pp. 645 - 651
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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