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University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging

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Abstract

The UAB Nathan Shock Center focuses on comparative energetics and aging. Energetics, as defined for this purpose, encompasses the causes, mechanisms, and consequences of the acquisition, storage, and use of metabolizable energy. Comparative energetics is the study of metabolic processes at multiple scales and across multiple species as it relates to health and aging. The link between energetics and aging is increasingly understood in terms of dysregulated mitochondrial function, altered metabolic signaling, and aberrant nutrient responsiveness with increasing age. The center offers world-class expertise in comprehensive, integrated energetic assessment and analysis from the level of the organelle to the organism and across species from the size of worms to rats as well as state-of-the-art data analytics. The range of services offered by our three research cores, (1) The Organismal Energetics Core, (2) Mitometabolism Core, and (3) Data Analytics Core, is described herein.

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Authors and Affiliations

  1. Department of Biology, University of Alabama At Birmingham, Birmingham, AL, USA

    Steven N. Austad & Liou Sun

  2. Department of Medicine, University of Alabama At Birmingham, Birmingham, AL, USA

    Thomas W. Buford & Christy S. Carter

  3. Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA

    David B. Allison

  4. Department of Pathology, University of Alabama At Birmingham, Birmingham, AL, USA

    Scott. W. Ballinger, Victor M. Darley-Usmar & Jianhua Zhang

  5. Department of Applied Health Sciences, Indiana University-Bloomington, Bloomington, USA

    Andrew W. Brown

  6. Department of Genetics, University of Alabama At Birmingham, Birmingham, AL, USA

    John L. Hartman

  7. Department of Nutrition Sciences, University of Alabama At Birmingham, Birmingham, AL, USA

    Timothy R. Nagy & Daniel L. Smith Jr

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  1. Steven N. Austad
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  2. Thomas W. Buford
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Correspondence to Steven N. Austad.

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Austad, S.N., Buford, T.W., Allison, D.B. et al. University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging . GeroScience 43, 2149–2160 (2021). https://doi.org/10.1007/s11357-021-00414-1

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