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Prevalence of sleep disturbances and their effects on quality of life in adults with untreated pituitary tumor and meningioma

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Abstract

Purpose

To explore the prevalence of sleep disturbances and their effects on quality of life in adults with pituitary tumor or meningioma.

Methods

This prospective study included 33 and 44 patients with pituitary tumor and meningioma, respectively. All participants completed a series of valid questionnaires for assessing sleep and quality of life; all participants wore 3-day actigraph prior to related treatment. The actigraph-derived sleep parameters included total sleep time, sleep onset latency, wake after sleep onset, sleep efficiency, and dichotomy index (I < O) value.

Results

The prevalence of insomnia, excessive daytime sleepiness, and poor sleep quality was 46.8%, 6.5%, and 81.8%, respectively. The differences in these sleep parameters between patients with pituitary tumor and those with meningioma were nonsignificant. Only 27 participants completed the actigraphic assessments. The mean I < O value was 95.99%, and nearly 60% participants exhibited circadian rhythm disruption. Sleep quality was the only sleep variable independently correlated with preoperative quality of life, even after adjustments for confounders (B = 0.80, p = 0.02).

Conclusions

Insomnia, poor sleep quality, and disrupted circadian rhythm are highly prevalent in adults with untreated pituitary tumor or meningioma. Sleep quality independently correlated with quality of life. We indirectly confirmed that tumor location may not be a possible cause of sleep changes.

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Data availability

Data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This study was supported by grants from Chang Gung Memorial Hospital (CMRPG2K0251 and CLRPG2L0051) and the Ministry of Science and Technology, Taiwan (MOST 110-2628-B-038-017).

Author information

Author notes

  1. Mei-Ru Lin and Pin-Yuan Chen have contributed equally to this work.

Authors and Affiliations

  1. Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan

    Mei-Ru Lin

  2. School of Nursing, College of Nursing, Taipei Medical University, 250 Wu-Hsing St, Taipei, 110, Taiwan

    Mei-Ru Lin, Pei-Ching Lin & Hsiao-Yean Chiu

  3. Department of Neurosurgery and Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung branch, Keelung, Taiwan

    Pin-Yuan Chen

  4. School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Pin-Yuan Chen

  5. Division of Neurosurgery, Department of Surgery Organization, National Taiwan University Hospital, Taipei, Taiwan

    Huan-Chih Wang

  6. Division of Neurosurgery, Department of Surgery Organization, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan

    Huan-Chih Wang

  7. Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan

    Hsin-Chien Lee

  8. Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Hsin-Chien Lee & Hsiao-Yean Chiu

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  1. Mei-Ru Lin
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Contributions

HYC, PYC, and MRL conceptualized and designed the study, assisted in data collection, analyzed the data, and drafted the initial manuscript; HYC, PYC, and MRL critically analyzed the data and reviewed the manuscript. HCW, PCL, and HCL helped in data collection and critically reviewed the manuscript. All authors have approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Correspondence to Hsiao-Yean Chiu.

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Lin, MR., Chen, PY., Wang, HC. et al. Prevalence of sleep disturbances and their effects on quality of life in adults with untreated pituitary tumor and meningioma. J Neurooncol 154, 179–186 (2021). https://doi.org/10.1007/s11060-021-03811-w

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  • DOI: https://doi.org/10.1007/s11060-021-03811-w

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